A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus
Gestational diabetes mellitus is a progressive and complex pregnancy complication, which threatens both maternal and fetal health. It is urgent to screen for specific biomarkers for early diagnosis and precise treatment, as well as to identify key moleculars to better understand the pathogenic mecha...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6450352 |
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| author | Tao Zhou Lu Huang Min Wang Daozhen Chen Zhong Chen Shi-Wen Jiang |
| author_facet | Tao Zhou Lu Huang Min Wang Daozhen Chen Zhong Chen Shi-Wen Jiang |
| author_sort | Tao Zhou |
| collection | DOAJ |
| description | Gestational diabetes mellitus is a progressive and complex pregnancy complication, which threatens both maternal and fetal health. It is urgent to screen for specific biomarkers for early diagnosis and precise treatment, as well as to identify key moleculars to better understand the pathogenic mechanisms. In the present review, we comprehensively summarized recent studies of gestational diabetes using mass spectrometry-based proteomic technologies. Focused on the entire experimental design and proteomic results, we showed that these studies have covered a broad range of research contents in terms of sampling time, sample types, and outcome associations. Although most of the studies only stayed in the stage of initial discovery, several proteins were further verified to be efficient for disease diagnosis. Functional analysis of all the combined significant proteins also showed that a small number of proteins are known to be involved in the regulation of insulin or indirect signaling pathways. However, many factors such as diagnostic criteria, sample processing, proteomic method, and statistical method can greatly affect the identification of reproducible and reliable protein candidates. Thus, we further provided constructive suggestions and recommendations for carrying out proteomic or follow-up studies of gestational diabetes or other pregnancy complications in the future. |
| format | Article |
| id | doaj-art-c99baf1f38e74d588e97fada031b6be9 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c99baf1f38e74d588e97fada031b6be92025-02-03T06:46:19ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/64503526450352A Critical Review of Proteomic Studies in Gestational Diabetes MellitusTao Zhou0Lu Huang1Min Wang2Daozhen Chen3Zhong Chen4Shi-Wen Jiang5Research Institute for Reproductive Medicine and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaDepartment of Obstetrics, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaCentre for Reproductive Medicine, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaResearch Institute for Reproductive Medicine and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaDepartment of Obstetrics, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaResearch Institute for Reproductive Medicine and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, ChinaGestational diabetes mellitus is a progressive and complex pregnancy complication, which threatens both maternal and fetal health. It is urgent to screen for specific biomarkers for early diagnosis and precise treatment, as well as to identify key moleculars to better understand the pathogenic mechanisms. In the present review, we comprehensively summarized recent studies of gestational diabetes using mass spectrometry-based proteomic technologies. Focused on the entire experimental design and proteomic results, we showed that these studies have covered a broad range of research contents in terms of sampling time, sample types, and outcome associations. Although most of the studies only stayed in the stage of initial discovery, several proteins were further verified to be efficient for disease diagnosis. Functional analysis of all the combined significant proteins also showed that a small number of proteins are known to be involved in the regulation of insulin or indirect signaling pathways. However, many factors such as diagnostic criteria, sample processing, proteomic method, and statistical method can greatly affect the identification of reproducible and reliable protein candidates. Thus, we further provided constructive suggestions and recommendations for carrying out proteomic or follow-up studies of gestational diabetes or other pregnancy complications in the future.http://dx.doi.org/10.1155/2020/6450352 |
| spellingShingle | Tao Zhou Lu Huang Min Wang Daozhen Chen Zhong Chen Shi-Wen Jiang A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus Journal of Diabetes Research |
| title | A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus |
| title_full | A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus |
| title_fullStr | A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus |
| title_full_unstemmed | A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus |
| title_short | A Critical Review of Proteomic Studies in Gestational Diabetes Mellitus |
| title_sort | critical review of proteomic studies in gestational diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/6450352 |
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