Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report
Sertoli-Leydig cell tumors are a rare type of sex cord-stromal tumors that are mostly hormonally active (androgenic or estrogenic). Owing to the rarity of this disease, its impact on pregnancy is not fully understood. This report concerns a rare case of a Sertoli-Leydig cell tumor incidentally disco...
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Elsevier
2025-10-01
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| Series: | Case Reports in Women's Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214911225000633 |
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| author | Roza Mahyoob Keisuke Sugita Akiko Yamamoto |
| author_facet | Roza Mahyoob Keisuke Sugita Akiko Yamamoto |
| author_sort | Roza Mahyoob |
| collection | DOAJ |
| description | Sertoli-Leydig cell tumors are a rare type of sex cord-stromal tumors that are mostly hormonally active (androgenic or estrogenic). Owing to the rarity of this disease, its impact on pregnancy is not fully understood. This report concerns a rare case of a Sertoli-Leydig cell tumor incidentally discovered during a cesarean section. In a resource-poor setting, a 21-year-old woman was referred to hospital for her first childbirth. She had clitoromegaly for a few years, had never had a gynecological consultation, and had not received antenatal care during this pregnancy. Three hours after admission, an emergency cesarean section was indicated because of fetal distress. During the procedure, a right ovarian tumor measuring approximately 10 × 10 cm was found. Considering the patient's age and obstetric history, and the inability to perform histological evaluation during surgery at the hospital she attended, the decision was made to proceed only with tumor resection. Considering the possibility of a sex-cord stromal tumor focusing on the clitoromegaly, histopathological evaluation was performed, and a diagnosis of a Sertoli-Leydig cell tumor was obtained. This case underscores the importance of clinical vigilance for rare hormonally active ovarian tumors during pregnancy, particularly in low-resource settings. |
| format | Article |
| id | doaj-art-c9865d84c531439bbe19122ca4225b7d |
| institution | Kabale University |
| issn | 2214-9112 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Reports in Women's Health |
| spelling | doaj-art-c9865d84c531439bbe19122ca4225b7d2025-08-20T04:01:01ZengElsevierCase Reports in Women's Health2214-91122025-10-0147e0074210.1016/j.crwh.2025.e00742Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case reportRoza Mahyoob0Keisuke Sugita1Akiko Yamamoto2Department of Obstetrics, Mocha General Hospital, Médecins Sans Frontières- Belgique (OCB), YemenDepartment of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Institute of Science, Tokyo, JapanDepartment of Obstetrics, Mocha General Hospital, Médecins Sans Frontières- Belgique (OCB), Yemen; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Institute of Science, Tokyo, Japan; Corresponding author at : Médecins Sans Frontières- Belgique (OCB) Mocha, Taiz, Yemen.Sertoli-Leydig cell tumors are a rare type of sex cord-stromal tumors that are mostly hormonally active (androgenic or estrogenic). Owing to the rarity of this disease, its impact on pregnancy is not fully understood. This report concerns a rare case of a Sertoli-Leydig cell tumor incidentally discovered during a cesarean section. In a resource-poor setting, a 21-year-old woman was referred to hospital for her first childbirth. She had clitoromegaly for a few years, had never had a gynecological consultation, and had not received antenatal care during this pregnancy. Three hours after admission, an emergency cesarean section was indicated because of fetal distress. During the procedure, a right ovarian tumor measuring approximately 10 × 10 cm was found. Considering the patient's age and obstetric history, and the inability to perform histological evaluation during surgery at the hospital she attended, the decision was made to proceed only with tumor resection. Considering the possibility of a sex-cord stromal tumor focusing on the clitoromegaly, histopathological evaluation was performed, and a diagnosis of a Sertoli-Leydig cell tumor was obtained. This case underscores the importance of clinical vigilance for rare hormonally active ovarian tumors during pregnancy, particularly in low-resource settings.http://www.sciencedirect.com/science/article/pii/S2214911225000633Sertoli-Leydig cell tumorPregnancyVirilizationSex cord-stromal ovarian tumorYemen |
| spellingShingle | Roza Mahyoob Keisuke Sugita Akiko Yamamoto Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report Case Reports in Women's Health Sertoli-Leydig cell tumor Pregnancy Virilization Sex cord-stromal ovarian tumor Yemen |
| title | Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report |
| title_full | Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report |
| title_fullStr | Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report |
| title_full_unstemmed | Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report |
| title_short | Incidental detection of a virilizing Sertoli-Leydig cell tumor during cesarean section: A case report |
| title_sort | incidental detection of a virilizing sertoli leydig cell tumor during cesarean section a case report |
| topic | Sertoli-Leydig cell tumor Pregnancy Virilization Sex cord-stromal ovarian tumor Yemen |
| url | http://www.sciencedirect.com/science/article/pii/S2214911225000633 |
| work_keys_str_mv | AT rozamahyoob incidentaldetectionofavirilizingsertolileydigcelltumorduringcesareansectionacasereport AT keisukesugita incidentaldetectionofavirilizingsertolileydigcelltumorduringcesareansectionacasereport AT akikoyamamoto incidentaldetectionofavirilizingsertolileydigcelltumorduringcesareansectionacasereport |