Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging

Abstract Background The human cornea is a transparent and uniquely ordered optical-biological system. Precise coordination of its cellular mechanisms is essential to maintain its transparency and functionality. However, the spatial, cellular and molecular architecture of the human cornea and its int...

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Main Authors: Dan Jiang, Ke Li, Yining Sun, Zicheng Zhang, Shuang Xie, Xintong Yu, Ruoqi Wang, Ying Feng, Qinxiang Zheng, Yajing Wen, Peter S. Reinach, Yuanyuan Du, Meng Zhou, Wei Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Medicine
Subjects:
Cornea
Aging
scStereo-seq
scRNA-seq
Spatial transcriptomics
Online Access:https://doi.org/10.1186/s13073-025-01475-z
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