mRNA therapy: A new frontier in regenerative medicine
Abstract Tissue regeneration has raised intensive attention due to its great significance in overcoming various diseases resulting from different injuries. Since the COVID‐19 pandemic, mRNA therapeutics have emerged as innovative strategies in the prevention and treatment of diseases due to their un...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-03-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20240054 |
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| author | Ding‐Ding Xue Yue Zhang An‐Ran Shen Tao‐Tao Tang Bi‐Cheng Liu Lin‐Li Lv |
| author_facet | Ding‐Ding Xue Yue Zhang An‐Ran Shen Tao‐Tao Tang Bi‐Cheng Liu Lin‐Li Lv |
| author_sort | Ding‐Ding Xue |
| collection | DOAJ |
| description | Abstract Tissue regeneration has raised intensive attention due to its great significance in overcoming various diseases resulting from different injuries. Since the COVID‐19 pandemic, mRNA therapeutics have emerged as innovative strategies in the prevention and treatment of diseases due to their unique advantages. Compared to traditional regenerative strategies, mRNA therapy offers rapid translation into proteins with low production cost and high modifiability. Herein, we discuss the progress in the key processes of mRNA therapy, focusing on therapeutic mRNA modification and delivery carriers. The preclinical and clinical studies of mRNA therapeutics for regeneration of cardiac, lung, liver, kidney, locomotor system, skin lesions and neurological disorders were summarized comprehensively. Developing strategies to reduce immunogenicity and off‐target effects, as well as optimization of the delivery system may accelerate the pace of clinical translation. |
| format | Article |
| id | doaj-art-c97f98a31e6c47e4bba76bfb65ff13a0 |
| institution | OA Journals |
| issn | 2832-6245 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj-art-c97f98a31e6c47e4bba76bfb65ff13a02025-08-20T01:50:05ZengWiley-VCHInterdisciplinary Medicine2832-62452025-03-0132n/an/a10.1002/INMD.20240054mRNA therapy: A new frontier in regenerative medicineDing‐Ding Xue0Yue Zhang1An‐Ran Shen2Tao‐Tao Tang3Bi‐Cheng Liu4Lin‐Li Lv5Institute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaInstitute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaInstitute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaInstitute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaInstitute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaInstitute of Nephrology Southeast University School of Medicine Zhong Da Hospital Nanjing ChinaAbstract Tissue regeneration has raised intensive attention due to its great significance in overcoming various diseases resulting from different injuries. Since the COVID‐19 pandemic, mRNA therapeutics have emerged as innovative strategies in the prevention and treatment of diseases due to their unique advantages. Compared to traditional regenerative strategies, mRNA therapy offers rapid translation into proteins with low production cost and high modifiability. Herein, we discuss the progress in the key processes of mRNA therapy, focusing on therapeutic mRNA modification and delivery carriers. The preclinical and clinical studies of mRNA therapeutics for regeneration of cardiac, lung, liver, kidney, locomotor system, skin lesions and neurological disorders were summarized comprehensively. Developing strategies to reduce immunogenicity and off‐target effects, as well as optimization of the delivery system may accelerate the pace of clinical translation.https://doi.org/10.1002/INMD.20240054extracellular vesicleslipid nanoparticlesmRNA deliverymRNA therapyregeneration medicinetissue regeneration |
| spellingShingle | Ding‐Ding Xue Yue Zhang An‐Ran Shen Tao‐Tao Tang Bi‐Cheng Liu Lin‐Li Lv mRNA therapy: A new frontier in regenerative medicine Interdisciplinary Medicine extracellular vesicles lipid nanoparticles mRNA delivery mRNA therapy regeneration medicine tissue regeneration |
| title | mRNA therapy: A new frontier in regenerative medicine |
| title_full | mRNA therapy: A new frontier in regenerative medicine |
| title_fullStr | mRNA therapy: A new frontier in regenerative medicine |
| title_full_unstemmed | mRNA therapy: A new frontier in regenerative medicine |
| title_short | mRNA therapy: A new frontier in regenerative medicine |
| title_sort | mrna therapy a new frontier in regenerative medicine |
| topic | extracellular vesicles lipid nanoparticles mRNA delivery mRNA therapy regeneration medicine tissue regeneration |
| url | https://doi.org/10.1002/INMD.20240054 |
| work_keys_str_mv | AT dingdingxue mrnatherapyanewfrontierinregenerativemedicine AT yuezhang mrnatherapyanewfrontierinregenerativemedicine AT anranshen mrnatherapyanewfrontierinregenerativemedicine AT taotaotang mrnatherapyanewfrontierinregenerativemedicine AT bichengliu mrnatherapyanewfrontierinregenerativemedicine AT linlilv mrnatherapyanewfrontierinregenerativemedicine |