Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion
Abstract Persistent anti‐inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti‐adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the adv...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409128 |
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| author | Zaijin Tao Shuo Wang Jingwen Liu Tonghe Zhu Jia Jiang Shen Liu Xin Ma |
| author_facet | Zaijin Tao Shuo Wang Jingwen Liu Tonghe Zhu Jia Jiang Shen Liu Xin Ma |
| author_sort | Zaijin Tao |
| collection | DOAJ |
| description | Abstract Persistent anti‐inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti‐adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi‐functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester‐ and carbamate‐bonded CA (PEUU‐CA). PEUU‐CA is electrospun into bioactive patches that can uniquely present a sustained CA niche, referred to as BPSN. In the early stage of degradation, the breakage of the ester bond from BPSN is the dominant factor contributing to the early release of CA. In the later stage of BPSN degradation, the breakage of the ester and carbamate bonds contributes to the sustained release of CA. In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down‐regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage‐dominated biomaterial implantation and the issue of the short‐term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well‐known implant‐derived inflammatory responses. |
| format | Article |
| id | doaj-art-c97f7679f912433695b7e69d3193a5bc |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-c97f7679f912433695b7e69d3193a5bc2025-01-29T09:50:19ZengWileyAdvanced Science2198-38442025-01-01124n/an/a10.1002/advs.202409128Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous AntiadhesionZaijin Tao0Shuo Wang1Jingwen Liu2Tonghe Zhu3Jia Jiang4Shen Liu5Xin Ma6Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaDepartment of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaDepartment of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaMultidisciplinary Centre for Advanced Materials Institute for Frontier Medical Technology School of Chemistry and Chemical Engineering Shanghai University of Engineering Science 333 Longteng Rd. Shanghai 201620 P. R. ChinaDepartment of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaDepartment of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaDepartment of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 600 Yishan Rd. Shanghai 200233 P. R. ChinaAbstract Persistent anti‐inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti‐adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi‐functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester‐ and carbamate‐bonded CA (PEUU‐CA). PEUU‐CA is electrospun into bioactive patches that can uniquely present a sustained CA niche, referred to as BPSN. In the early stage of degradation, the breakage of the ester bond from BPSN is the dominant factor contributing to the early release of CA. In the later stage of BPSN degradation, the breakage of the ester and carbamate bonds contributes to the sustained release of CA. In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down‐regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage‐dominated biomaterial implantation and the issue of the short‐term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well‐known implant‐derived inflammatory responses.https://doi.org/10.1002/advs.202409128foreign body reactionspersistent immunomodulation (PIM)P2Y12tendon adhesion |
| spellingShingle | Zaijin Tao Shuo Wang Jingwen Liu Tonghe Zhu Jia Jiang Shen Liu Xin Ma Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion Advanced Science foreign body reactions persistent immunomodulation (PIM) P2Y12 tendon adhesion |
| title | Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion |
| title_full | Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion |
| title_fullStr | Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion |
| title_full_unstemmed | Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion |
| title_short | Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion |
| title_sort | sustainable immunomodulatory via macrophage p2y12 inhibition mediated bioactive patche for peritendinous antiadhesion |
| topic | foreign body reactions persistent immunomodulation (PIM) P2Y12 tendon adhesion |
| url | https://doi.org/10.1002/advs.202409128 |
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