Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions
The intestinal mucosa is unique in that it can be tolerant to the resident, symbiotic microbiota but remaining, at the same time, responsive to and able to fight pathogens. The close interaction between host-symbiotic microbiota at the mucosal level poses important challenges since microbial breache...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2010/386956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562005731442688 |
|---|---|
| author | Rodrigo Bibiloni Eduardo J. Schiffrin |
| author_facet | Rodrigo Bibiloni Eduardo J. Schiffrin |
| author_sort | Rodrigo Bibiloni |
| collection | DOAJ |
| description | The intestinal mucosa is unique in that it can be tolerant to the resident, symbiotic microbiota but remaining, at the same time, responsive to and able to fight pathogens. The close interaction between host-symbiotic microbiota at the mucosal level poses important challenges since microbial breaches through the gut barrier can result in the breakdown of gut homeostasis. In this paper, hosts-integrated components that help to preserve intestinal homeostasis including barrier and immune function are discussed. In addition global alterations of the microbiota that can play a role in the initiation of an exaggerated inflammatory response through an abnormal signaling of the innate and adaptive immune response are briefly described. |
| format | Article |
| id | doaj-art-c96e94454ae94dd9bc695c0e23832e7b |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-c96e94454ae94dd9bc695c0e23832e7b2025-02-03T01:23:40ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/386956386956Intestinal Host-Microbe Interactions under Physiological and Pathological ConditionsRodrigo Bibiloni0Eduardo J. Schiffrin1Ruakura Research Centre, AgResearch Ltd., East Street, Private Bag 3123, Hamilton 3240, New ZealandHealthCare Nutrition, Research and Development, Nestlé Nutrition, Nestec Ltd., Avenue Reller 14, 1800 Vevey, SwitzerlandThe intestinal mucosa is unique in that it can be tolerant to the resident, symbiotic microbiota but remaining, at the same time, responsive to and able to fight pathogens. The close interaction between host-symbiotic microbiota at the mucosal level poses important challenges since microbial breaches through the gut barrier can result in the breakdown of gut homeostasis. In this paper, hosts-integrated components that help to preserve intestinal homeostasis including barrier and immune function are discussed. In addition global alterations of the microbiota that can play a role in the initiation of an exaggerated inflammatory response through an abnormal signaling of the innate and adaptive immune response are briefly described.http://dx.doi.org/10.4061/2010/386956 |
| spellingShingle | Rodrigo Bibiloni Eduardo J. Schiffrin Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions International Journal of Inflammation |
| title | Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions |
| title_full | Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions |
| title_fullStr | Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions |
| title_full_unstemmed | Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions |
| title_short | Intestinal Host-Microbe Interactions under Physiological and Pathological Conditions |
| title_sort | intestinal host microbe interactions under physiological and pathological conditions |
| url | http://dx.doi.org/10.4061/2010/386956 |
| work_keys_str_mv | AT rodrigobibiloni intestinalhostmicrobeinteractionsunderphysiologicalandpathologicalconditions AT eduardojschiffrin intestinalhostmicrobeinteractionsunderphysiologicalandpathologicalconditions |