Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma

Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is among the most aggressive malignancies, underscoring the need for early diagnosis to improve patient outcomes. Tumor-derived exosomes, which can be non-invasively obtained and reflect the metabolic state of tumors in real-time, are...

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Bibliographic Details
Main Authors: Xi Chen, Fei Song, Peng Xiao, Yisong Yao, Dongxian Li, Yuhui Fang, Shijun Lv, Yakui Mou, Yumei Li, Xicheng Song
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
HNSCC
Spermine synthase
Metabolomics
Liquid chromatography–mass spectrometry
Diagnostic biomarkers
Tumor metabolism
Online Access:https://doi.org/10.1186/s12885-025-13820-x
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