Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function

Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function

Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating DSAs do not manifest rejection responses, suggesting a degree o...

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Bibliographic Details
Main Authors: Tanusya Murali Murali, Yue Gu, Rabiatul Adawiyah Minhat, Jiawei Yap, Kathryn J. Wood, Cheng-I Wang, Nicholas R. J. Gascoigne, Vathsala Anantharaman, Paul Anthony MacAry
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
alloantibodies
transplantation
antibody mediated rejection
human leukocyte antigen
antibody pathogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1438285/full
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