Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress
Abstract Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced toclinical medicine for more than a decade, while its pharmacological properties arestill not to be well addressed. This report aimed to explore theanti-atherosclerosis properties and underlying mechanisms of YD. We...
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Nature Portfolio
2015-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/srep12333 |
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| author | Long Cheng Guo-feng Pan Xiao-dong Zhang Jian-lu Wang Wan-dan Wang Jian-yong Zhang Hui Wang Ri-xin Liang Xiao-bo Sun |
| author_facet | Long Cheng Guo-feng Pan Xiao-dong Zhang Jian-lu Wang Wan-dan Wang Jian-yong Zhang Hui Wang Ri-xin Liang Xiao-bo Sun |
| author_sort | Long Cheng |
| collection | DOAJ |
| description | Abstract Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced toclinical medicine for more than a decade, while its pharmacological properties arestill not to be well addressed. This report aimed to explore theanti-atherosclerosis properties and underlying mechanisms of YD. We initiallyperformed a computational prediction based on a network pharmacology simulation,which clued YD exerted synergistically anti-atherosclerosis properties by vascularendothelium protection, lipid-lowering, anti-inflammation and anti-oxidation. Theseoutcomes were then validated in atherosclerosis rats. The experiments providedevidences indicating YD’s contribution in this study included, (1)significantly reduced the severity of atherosclerosis, inhibited reconstruction ofthe artery wall and regulated the lipid profile; (2) enhanced antioxidant power,strengthened the activity of antioxidant enzymes and decreased malondialdhydelevels; (3) significantly increased the viability of umbilical vein endothelialcells exposed to oxidative stress due to pretreatment with YD; (4) significantlyreduced the level of pro-inflammatory cytokines; (5) significantly down-regulatedNF-kB/p65 and up-regulated IkB in the YD-treated groups. Overall, these resultsdemonstrated that YD intervention relieves atherosclerosis through regulatinglipids, reducing lipid particle deposition in the endothelial layer of artery,enhancing antioxidant power and repressing inflammation activity by inhibiting thenuclear factor-kappa B signal pathway. |
| format | Article |
| id | doaj-art-c95960d70faf4f5680018a4bfb16148a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c95960d70faf4f5680018a4bfb16148a2025-01-19T12:25:04ZengNature PortfolioScientific Reports2045-23222015-07-015111110.1038/srep12333Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progressLong Cheng0Guo-feng Pan1Xiao-dong Zhang2Jian-lu Wang3Wan-dan Wang4Jian-yong Zhang5Hui Wang6Ri-xin Liang7Xiao-bo Sun8Key Laboratory of Bioactive Substances and Resources Utilizationof Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal PlantDevelopment, Chinese Academy of Medical Sciences and Peking Union MedicalCollegeDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital affiliated with Capital Medical UniversityCenter for Drug Evaluation, China Food and DrugAdministrationInstitute of Medicia Materia, China Academy of Chinese MedicalSciencesInstitute of Medicia Materia, China Academy of Chinese MedicalSciencesZunyi Medical UniversityGuang’anmen Hospital, China Academy of ChineseMedical SciencesInstitute of Medicia Materia, China Academy of Chinese MedicalSciencesKey Laboratory of Bioactive Substances and Resources Utilizationof Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal PlantDevelopment, Chinese Academy of Medical Sciences and Peking Union MedicalCollegeAbstract Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced toclinical medicine for more than a decade, while its pharmacological properties arestill not to be well addressed. This report aimed to explore theanti-atherosclerosis properties and underlying mechanisms of YD. We initiallyperformed a computational prediction based on a network pharmacology simulation,which clued YD exerted synergistically anti-atherosclerosis properties by vascularendothelium protection, lipid-lowering, anti-inflammation and anti-oxidation. Theseoutcomes were then validated in atherosclerosis rats. The experiments providedevidences indicating YD’s contribution in this study included, (1)significantly reduced the severity of atherosclerosis, inhibited reconstruction ofthe artery wall and regulated the lipid profile; (2) enhanced antioxidant power,strengthened the activity of antioxidant enzymes and decreased malondialdhydelevels; (3) significantly increased the viability of umbilical vein endothelialcells exposed to oxidative stress due to pretreatment with YD; (4) significantlyreduced the level of pro-inflammatory cytokines; (5) significantly down-regulatedNF-kB/p65 and up-regulated IkB in the YD-treated groups. Overall, these resultsdemonstrated that YD intervention relieves atherosclerosis through regulatinglipids, reducing lipid particle deposition in the endothelial layer of artery,enhancing antioxidant power and repressing inflammation activity by inhibiting thenuclear factor-kappa B signal pathway.https://doi.org/10.1038/srep12333 |
| spellingShingle | Long Cheng Guo-feng Pan Xiao-dong Zhang Jian-lu Wang Wan-dan Wang Jian-yong Zhang Hui Wang Ri-xin Liang Xiao-bo Sun Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress Scientific Reports |
| title | Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress |
| title_full | Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress |
| title_fullStr | Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress |
| title_full_unstemmed | Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress |
| title_short | Yindanxinnaotong, a Chinese compound medicine, synergistically attenuatesatherosclerosis progress |
| title_sort | yindanxinnaotong a chinese compound medicine synergistically attenuatesatherosclerosis progress |
| url | https://doi.org/10.1038/srep12333 |
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