Targeting necroptosis in Alzheimer’s disease: can exercise modulate neuronal death?

Targeting necroptosis in Alzheimer’s disease: can exercise modulate neuronal death?

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and neuronal degeneration. Emerging evidence implicates necroptosis in AD pathogenesis, driven by the RIPK1-RIPK3-MLKL pathway, which promotes neuronal damage, inflammation, and disease progression. Exercise,...

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Bibliographic Details
Main Authors: Donglei Lu, Wenyu Zhang, Ruiyu Li, Sijie Tan, Yan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
necroptosis
exercise
neuronal degeneration
cognitive function
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1499871/full
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