Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.
Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. pallidum genomes (two from T. pallid...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-06-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006447&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230196979892224 |
|---|---|
| author | Verena J Schuenemann Aditya Kumar Lankapalli Rodrigo Barquera Elizabeth A Nelson Diana Iraíz Hernández Víctor Acuña Alonzo Kirsten I Bos Lourdes Márquez Morfín Alexander Herbig Johannes Krause |
| author_facet | Verena J Schuenemann Aditya Kumar Lankapalli Rodrigo Barquera Elizabeth A Nelson Diana Iraíz Hernández Víctor Acuña Alonzo Kirsten I Bos Lourdes Márquez Morfín Alexander Herbig Johannes Krause |
| author_sort | Verena J Schuenemann |
| collection | DOAJ |
| description | Treponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. pallidum genomes (two from T. pallidum ssp. pallidum and one from T. pallidum ssp. pertenue) that have been reconstructed from skeletons recovered from the Convent of Santa Isabel in Mexico City, operational between the 17th and 19th century. Our analyses indicate that different T. pallidum subspecies caused similar diagnostic presentations that are normally associated with syphilis in infants, and potential evidence of a congenital infection of T. pallidum ssp. pertenue, the causative agent of yaws. This first reconstruction of T. pallidum genomes from archaeological material opens the possibility of studying its evolutionary history at a resolution previously assumed to be out of reach. |
| format | Article |
| id | doaj-art-c9572aff4e86403faaa48e1eaec4d66e |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-c9572aff4e86403faaa48e1eaec4d66e2025-08-20T02:03:57ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352018-06-01126e000644710.1371/journal.pntd.0006447Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains.Verena J SchuenemannAditya Kumar LankapalliRodrigo BarqueraElizabeth A NelsonDiana Iraíz HernándezVíctor Acuña AlonzoKirsten I BosLourdes Márquez MorfínAlexander HerbigJohannes KrauseTreponema pallidum infections occur worldwide causing, among other diseases, syphilis and yaws. In particular sexually transmitted syphilis is regarded as a re-emerging infectious disease with millions of new infections annually. Here we present three historic T. pallidum genomes (two from T. pallidum ssp. pallidum and one from T. pallidum ssp. pertenue) that have been reconstructed from skeletons recovered from the Convent of Santa Isabel in Mexico City, operational between the 17th and 19th century. Our analyses indicate that different T. pallidum subspecies caused similar diagnostic presentations that are normally associated with syphilis in infants, and potential evidence of a congenital infection of T. pallidum ssp. pertenue, the causative agent of yaws. This first reconstruction of T. pallidum genomes from archaeological material opens the possibility of studying its evolutionary history at a resolution previously assumed to be out of reach.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006447&type=printable |
| spellingShingle | Verena J Schuenemann Aditya Kumar Lankapalli Rodrigo Barquera Elizabeth A Nelson Diana Iraíz Hernández Víctor Acuña Alonzo Kirsten I Bos Lourdes Márquez Morfín Alexander Herbig Johannes Krause Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. PLoS Neglected Tropical Diseases |
| title | Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. |
| title_full | Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. |
| title_fullStr | Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. |
| title_full_unstemmed | Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. |
| title_short | Historic Treponema pallidum genomes from Colonial Mexico retrieved from archaeological remains. |
| title_sort | historic treponema pallidum genomes from colonial mexico retrieved from archaeological remains |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006447&type=printable |
| work_keys_str_mv | AT verenajschuenemann historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT adityakumarlankapalli historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT rodrigobarquera historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT elizabethanelson historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT dianairaizhernandez historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT victoracunaalonzo historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT kirstenibos historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT lourdesmarquezmorfin historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT alexanderherbig historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains AT johanneskrause historictreponemapallidumgenomesfromcolonialmexicoretrievedfromarchaeologicalremains |