Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences

Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences

ABSTRACT Recombination is a significant factor driving the evolution of RNA viruses. The prevalence and variation of porcine reproductive and respiratory syndrome virus (PRRSV) in China have been increasing in complexity due to extensive interlineage recombination. When this recombination phenomenon...

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Bibliographic Details
Main Authors:	Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-02-01
Series:	mBio
Subjects:	RNA recombination porcine reproductive and respiratory syndrome virus (PRRSV) transcriptional regulatory sequence (TRS) recombination-resistant vaccine redesign
Online Access:	https://journals.asm.org/doi/10.1128/mbio.02350-24
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