FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment

FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment

Abstract Background The demethylase fat mass and obesity-related associated protein (FTO) is strongly associated with depression. Aging is a risk factor for synaptic plasticity damage in the brain and leads to neurocognitive dysfunctions. FTO-dependent m6A modification plays an important role in neu...

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Bibliographic Details
Main Authors: Mengdie Li, Yating Yang, Tangcong Chen, Yueyang Luo, Yingqian Zhang, Huanzhong Liu, Michael Maes
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Behavioral and Brain Functions
Subjects:
FTO
Chronic unpredictable mild stress (CUMS)
Cognitive impairment
Synaptic plasticity
BDNF-TrkB signaling pathway
Online Access:https://doi.org/10.1186/s12993-025-00280-3
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