The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy
Background: Anastomotic leakage is a severe complication of esophagectomy, therefore early detection is crucial. Presepsin is a biomarker for early diagnosis of infectious complications. This study assessed presepsin as a biomarker for anastomotic leakage after esophagectomy, compared to C-reactive...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Surgery Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258984502500003X |
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| author | Yoshiro Imai Ryo Tanaka Kentaro Matsuo Hidero Yoshimoto Mitsuhiro Asakuma Hideki Tomiyama Sang-Woong Lee |
| author_facet | Yoshiro Imai Ryo Tanaka Kentaro Matsuo Hidero Yoshimoto Mitsuhiro Asakuma Hideki Tomiyama Sang-Woong Lee |
| author_sort | Yoshiro Imai |
| collection | DOAJ |
| description | Background: Anastomotic leakage is a severe complication of esophagectomy, therefore early detection is crucial. Presepsin is a biomarker for early diagnosis of infectious complications. This study assessed presepsin as a biomarker for anastomotic leakage after esophagectomy, compared to C-reactive protein (CRP), white blood cells (WBCs), and neutrophils (Neuts). Materials and methods: This study enrolled 27 patients between October 2019 and December 2020. Levels of presepsin, CRP, WBCs, and Neuts were measured preoperatively and on postoperative days (PODs) 1, 3, 5, and 7. Results: Five patients had anastomotic leakage. Their presepsin levels on POD 7 were significantly higher and tended to be higher on POD 5 (p = 0.04 and p = 0.06, respectively) compared to those without leakage. The area under the curve values for presepsin were highest on PODs 5 and 7 (0.89 and 0.83). Optimal cut-off values for presepsin were 400 pg/mL (sensitivity 100 %; specificity 81.9 %) on POD 5 and similar on POD 7. Conclusions: Presepsin levels on PODs 5 and 7 effectively detect anastomotic leakage after esophagectomy, making it a valuable, simple, non-invasive early detection test. |
| format | Article |
| id | doaj-art-c94ddd654300448487630c72ba04d891 |
| institution | Kabale University |
| issn | 2589-8450 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Surgery Open Science |
| spelling | doaj-art-c94ddd654300448487630c72ba04d8912025-01-31T05:12:18ZengElsevierSurgery Open Science2589-84502025-01-01237580The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomyYoshiro Imai0Ryo Tanaka1Kentaro Matsuo2Hidero Yoshimoto3Mitsuhiro Asakuma4Hideki Tomiyama5Sang-Woong Lee6Corresponding author at: Department of General and Gastroenterological Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.; Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, JapanBackground: Anastomotic leakage is a severe complication of esophagectomy, therefore early detection is crucial. Presepsin is a biomarker for early diagnosis of infectious complications. This study assessed presepsin as a biomarker for anastomotic leakage after esophagectomy, compared to C-reactive protein (CRP), white blood cells (WBCs), and neutrophils (Neuts). Materials and methods: This study enrolled 27 patients between October 2019 and December 2020. Levels of presepsin, CRP, WBCs, and Neuts were measured preoperatively and on postoperative days (PODs) 1, 3, 5, and 7. Results: Five patients had anastomotic leakage. Their presepsin levels on POD 7 were significantly higher and tended to be higher on POD 5 (p = 0.04 and p = 0.06, respectively) compared to those without leakage. The area under the curve values for presepsin were highest on PODs 5 and 7 (0.89 and 0.83). Optimal cut-off values for presepsin were 400 pg/mL (sensitivity 100 %; specificity 81.9 %) on POD 5 and similar on POD 7. Conclusions: Presepsin levels on PODs 5 and 7 effectively detect anastomotic leakage after esophagectomy, making it a valuable, simple, non-invasive early detection test.http://www.sciencedirect.com/science/article/pii/S258984502500003XPresepsinEsophagectomyAnastomotic leakageEsophageal cancer |
| spellingShingle | Yoshiro Imai Ryo Tanaka Kentaro Matsuo Hidero Yoshimoto Mitsuhiro Asakuma Hideki Tomiyama Sang-Woong Lee The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy Surgery Open Science Presepsin Esophagectomy Anastomotic leakage Esophageal cancer |
| title | The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| title_full | The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| title_fullStr | The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| title_full_unstemmed | The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| title_short | The usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| title_sort | usefulness of presepsin in the early detection of anastomotic leakage after esophagectomy |
| topic | Presepsin Esophagectomy Anastomotic leakage Esophageal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S258984502500003X |
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