Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome
Ayu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese dia...
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| Format: | Article |
| Language: | English |
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2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/1583154 |
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| author | Takeshi Nishida Koichi Tsuneyama Yasuhiko Tago Koji Nomura Makoto Fujimoto Takahiko Nakajima Akira Noguchi Takashi Minamisaka Hideki Hatta Johji Imura |
| author_facet | Takeshi Nishida Koichi Tsuneyama Yasuhiko Tago Koji Nomura Makoto Fujimoto Takahiko Nakajima Akira Noguchi Takashi Minamisaka Hideki Hatta Johji Imura |
| author_sort | Takeshi Nishida |
| collection | DOAJ |
| description | Ayu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese diabetes (TSOD) mice model of spontaneous metabolic syndrome because useful LAB are known as probiotics that regulate intestinal function. In the present study, the increased body weight of the TSOD mice was attenuated in those fed the ayu-narezushi-comprised chow (ayu-narezushi group) compared with those fed the normal rodent chow (control group). Serum triglyceride and cholesterol levels were significantly lower in the Ayu-narezushi group than in the control group at 24 weeks of age. Furthermore, hepatic mRNA levels of carnitine-palmitoyl transferase 1 and acyl-CoA oxidase, which related to fatty acid oxidation, were significantly increased in the ayu-narezushi group than in the control group at 24 weeks of age. In conclusion, these results suggested that continuous feeding with ayu-narezushi improved obesity and dyslipidemia in the TSOD mice and that the activation of fatty acid oxidation in the liver might contribute to these improvements. |
| format | Article |
| id | doaj-art-c9484eb3f9074ab9b1b833e0c504441a |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c9484eb3f9074ab9b1b833e0c504441a2025-02-03T07:23:31ZengWileyThe Scientific World Journal2356-61401537-744X2021-01-01202110.1155/2021/15831541583154Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic SyndromeTakeshi Nishida0Koichi Tsuneyama1Yasuhiko Tago2Koji Nomura3Makoto Fujimoto4Takahiko Nakajima5Akira Noguchi6Takashi Minamisaka7Hideki Hatta8Johji Imura9Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, 3–18–15 Kuramoto, Tokushima 770–8503, JapanFisheries Research Institute, Toyama Prefectural Agricultural, Forestry & Fisheries Research Center, 364 Takatsuka, Namerikawa 936–8536, JapanFisheries Research Institute, Toyama Prefectural Agricultural, Forestry & Fisheries Research Center, 364 Takatsuka, Namerikawa 936–8536, JapanDepartment of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanDepartment of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930–0194, JapanAyu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese diabetes (TSOD) mice model of spontaneous metabolic syndrome because useful LAB are known as probiotics that regulate intestinal function. In the present study, the increased body weight of the TSOD mice was attenuated in those fed the ayu-narezushi-comprised chow (ayu-narezushi group) compared with those fed the normal rodent chow (control group). Serum triglyceride and cholesterol levels were significantly lower in the Ayu-narezushi group than in the control group at 24 weeks of age. Furthermore, hepatic mRNA levels of carnitine-palmitoyl transferase 1 and acyl-CoA oxidase, which related to fatty acid oxidation, were significantly increased in the ayu-narezushi group than in the control group at 24 weeks of age. In conclusion, these results suggested that continuous feeding with ayu-narezushi improved obesity and dyslipidemia in the TSOD mice and that the activation of fatty acid oxidation in the liver might contribute to these improvements.http://dx.doi.org/10.1155/2021/1583154 |
| spellingShingle | Takeshi Nishida Koichi Tsuneyama Yasuhiko Tago Koji Nomura Makoto Fujimoto Takahiko Nakajima Akira Noguchi Takashi Minamisaka Hideki Hatta Johji Imura Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome The Scientific World Journal |
| title | Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome |
| title_full | Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome |
| title_fullStr | Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome |
| title_full_unstemmed | Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome |
| title_short | Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome |
| title_sort | effect of continuous feeding of ayu narezushi on lipid metabolism in a mouse model of metabolic syndrome |
| url | http://dx.doi.org/10.1155/2021/1583154 |
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