Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

Abstract Aims Obesity increases the risk of heart failure with preserved (HFpEF), but not reduced ejection fraction (HFrEF). The glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide improves outcome of patients with obesity with or without HFpEF, while GLP‐1‐RAs were associated with adver...

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Main Authors: Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:ESC Heart Failure
Subjects:
Excitation‐contraction coupling
Glucagon‐like peptide agonists
Heart failure
Obesity
Semaglutide
Online Access:https://doi.org/10.1002/ehf2.15152
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