Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies
Methicillin-resistant Staphylococcus aureus (MRSA) infection gives rise to significant morbidity and carries a grave prognosis, resulting in the demise of approximately 21.8% of afflicted individuals on a yearly basis Staphylococcus aureus has the capability to induce a myriad of diverse diseases,...
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| Format: | Article |
| Language: | English |
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HH Publisher
2024-06-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/1025 |
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| author | Yi He Kuai Jodi Woan-Fei Law Yong Sze Ong Vengadesh Letchumanan Learn-Han Lee Loh Teng-Hern Tan |
| author_facet | Yi He Kuai Jodi Woan-Fei Law Yong Sze Ong Vengadesh Letchumanan Learn-Han Lee Loh Teng-Hern Tan |
| author_sort | Yi He Kuai |
| collection | DOAJ |
| description |
Methicillin-resistant Staphylococcus aureus (MRSA) infection gives rise to significant morbidity and carries a grave prognosis, resulting in the demise of approximately 21.8% of afflicted individuals on a yearly basis Staphylococcus aureus has the capability to induce a myriad of diverse diseases, a phenomenon attributed to its extensive array of virulence factors and formation of biofilms. The regulation of key virulence determinants, crucial for pathogenicity, is intricately controlled by the staphylococcal accessory regulatory (sarA) system. SarA plays a crucial role in the pathogenic mechanisms of S. aureus and the development of biofilms, while simultaneously modulating the synthesis of multiple virulence factors and influencing the expression of specific colonization determinants, and mutations in sarA partially limit the extent of S. aureus biofilms formation. In this review, we present an overview of the current understanding of the molecular mechanisms underlying the regulation of sarA gene expression, with a particular emphasis on its relevance in the development and sustenance of antimicrobial resistance, along with in the processes of biofilm formation and activation of virulence genes in MRSA. This review demonstrated that suppressing the expression of sarA gene exerts a notable impact on both biofilm development and the pathogenicity of MRSA strains, thereby offering a hopeful approach to the efficient management and treatment of MRSA infections.
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| format | Article |
| id | doaj-art-c9216c8c0d2b4870b0a2b3dfc16d208d |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-c9216c8c0d2b4870b0a2b3dfc16d208d2025-02-04T08:39:38ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492024-06-017110.36877/pmmb.a0000444Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies Yi He KuaiJodi Woan-Fei LawYong Sze OngVengadesh LetchumananLearn-Han LeeLoh Teng-Hern Tan Methicillin-resistant Staphylococcus aureus (MRSA) infection gives rise to significant morbidity and carries a grave prognosis, resulting in the demise of approximately 21.8% of afflicted individuals on a yearly basis Staphylococcus aureus has the capability to induce a myriad of diverse diseases, a phenomenon attributed to its extensive array of virulence factors and formation of biofilms. The regulation of key virulence determinants, crucial for pathogenicity, is intricately controlled by the staphylococcal accessory regulatory (sarA) system. SarA plays a crucial role in the pathogenic mechanisms of S. aureus and the development of biofilms, while simultaneously modulating the synthesis of multiple virulence factors and influencing the expression of specific colonization determinants, and mutations in sarA partially limit the extent of S. aureus biofilms formation. In this review, we present an overview of the current understanding of the molecular mechanisms underlying the regulation of sarA gene expression, with a particular emphasis on its relevance in the development and sustenance of antimicrobial resistance, along with in the processes of biofilm formation and activation of virulence genes in MRSA. This review demonstrated that suppressing the expression of sarA gene exerts a notable impact on both biofilm development and the pathogenicity of MRSA strains, thereby offering a hopeful approach to the efficient management and treatment of MRSA infections. https://journals.hh-publisher.com/index.php/pmmb/article/view/1025 |
| spellingShingle | Yi He Kuai Jodi Woan-Fei Law Yong Sze Ong Vengadesh Letchumanan Learn-Han Lee Loh Teng-Hern Tan Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies Progress in Microbes and Molecular Biology |
| title | Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies |
| title_full | Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies |
| title_fullStr | Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies |
| title_full_unstemmed | Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies |
| title_short | Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic Strategies |
| title_sort | role of sara in staphylococcus aureus a virulence target for therapeutic strategies |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/1025 |
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