A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts
The disinfection of drinking water is essential for eliminating pathogens and preventing waterborne diseases. However, this process generates various disinfection byproducts (DBPs), which toxicological research indicates can have detrimental effects on living organisms. Moreover, the safety of these...
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2025-01-01
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| author | Ying Liu Zhipeng Zhang Yuling Wu Huan Yang Jiao Qu Xiaolin Zhu |
| author_facet | Ying Liu Zhipeng Zhang Yuling Wu Huan Yang Jiao Qu Xiaolin Zhu |
| author_sort | Ying Liu |
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| description | The disinfection of drinking water is essential for eliminating pathogens and preventing waterborne diseases. However, this process generates various disinfection byproducts (DBPs), which toxicological research indicates can have detrimental effects on living organisms. Moreover, the safety of these DBPs has not been sufficiently assessed, underscoring the need for a comprehensive evaluation of their toxic effects and associated health risks. Compared to traditional methods for studying the toxicity of pollutants, emerging electrochemical sensing technologies offer advantages such as simplicity, speed, and sensitivity, presenting an effective means for toxicity research on pollutants. However, challenges remain in this field, including the need to improve electrode sensitivity and reduce electrode costs. In this study, a pencil graphite electrode (PGE) was modified with carboxylated multi-walled carbon nanotubes (MWCNT-COOH) and nano-iron (III) oxide (α-Fe<sub>2</sub>O<sub>3</sub>) to fabricate a low-cost electrode with excellent electrocatalytic performance for cell-active substances. Subsequently, a novel cellular electrochemical sensor was constructed for the sensitive detection of the toxicity of three drinking water DBPs. The half inhibitory concentration (IC<sub>50</sub>) values of 2-chlorophenylacetonitrile (2-CPAN), 3-chlorophenylacetonitrile (3-CPAN), and 4-chlorophenylacetonitrile (4-CPAN) for HepG2 cells were 660.69, 831.76, and 812.83 µM, respectively. This study provides technical support and scientific evidence for the toxicity detection and safety assessment of emerging contaminants. |
| format | Article |
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| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-c91a19d9d9054c849574faa7ca62a6d02025-01-24T13:44:18ZengMDPI AGNanomaterials2079-49912025-01-0115214610.3390/nano15020146A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection ByproductsYing Liu0Zhipeng Zhang1Yuling Wu2Huan Yang3Jiao Qu4Xiaolin Zhu5School of Environment, Northeast Normal University, Changchun 130117, ChinaSchool of Environment, Northeast Normal University, Changchun 130117, ChinaSchool of Environment, Northeast Normal University, Changchun 130117, ChinaSchool of Environment, Northeast Normal University, Changchun 130117, ChinaSchool of Environment, Northeast Normal University, Changchun 130117, ChinaSchool of Environment, Northeast Normal University, Changchun 130117, ChinaThe disinfection of drinking water is essential for eliminating pathogens and preventing waterborne diseases. However, this process generates various disinfection byproducts (DBPs), which toxicological research indicates can have detrimental effects on living organisms. Moreover, the safety of these DBPs has not been sufficiently assessed, underscoring the need for a comprehensive evaluation of their toxic effects and associated health risks. Compared to traditional methods for studying the toxicity of pollutants, emerging electrochemical sensing technologies offer advantages such as simplicity, speed, and sensitivity, presenting an effective means for toxicity research on pollutants. However, challenges remain in this field, including the need to improve electrode sensitivity and reduce electrode costs. In this study, a pencil graphite electrode (PGE) was modified with carboxylated multi-walled carbon nanotubes (MWCNT-COOH) and nano-iron (III) oxide (α-Fe<sub>2</sub>O<sub>3</sub>) to fabricate a low-cost electrode with excellent electrocatalytic performance for cell-active substances. Subsequently, a novel cellular electrochemical sensor was constructed for the sensitive detection of the toxicity of three drinking water DBPs. The half inhibitory concentration (IC<sub>50</sub>) values of 2-chlorophenylacetonitrile (2-CPAN), 3-chlorophenylacetonitrile (3-CPAN), and 4-chlorophenylacetonitrile (4-CPAN) for HepG2 cells were 660.69, 831.76, and 812.83 µM, respectively. This study provides technical support and scientific evidence for the toxicity detection and safety assessment of emerging contaminants.https://www.mdpi.com/2079-4991/15/2/146biosensordisinfection byproductscytotoxicitymulti-walled carbon nanotubesnano-iron (III) oxide |
| spellingShingle | Ying Liu Zhipeng Zhang Yuling Wu Huan Yang Jiao Qu Xiaolin Zhu A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts Nanomaterials biosensor disinfection byproducts cytotoxicity multi-walled carbon nanotubes nano-iron (III) oxide |
| title | A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts |
| title_full | A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts |
| title_fullStr | A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts |
| title_full_unstemmed | A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts |
| title_short | A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe<sub>2</sub>O<sub>3</sub> for Toxicity Detection of Drinking Water Disinfection Byproducts |
| title_sort | low cost electrochemical cell sensor based on mwcnt cooh α fe sub 2 sub o sub 3 sub for toxicity detection of drinking water disinfection byproducts |
| topic | biosensor disinfection byproducts cytotoxicity multi-walled carbon nanotubes nano-iron (III) oxide |
| url | https://www.mdpi.com/2079-4991/15/2/146 |
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