Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions
SADS-CoV, a recently identified <i>Rhinolophus</i> bat coronavirus HKU2-associated swine coronavirus, is a malignant pathogen that causes acute diarrhea, severe diarrhea, and weight loss in infected piglets. The virus was first detected in Guangdong Province, China, in 2017 and has since...
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MDPI AG
2025-01-01
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| author | Seung-Hwa Baek Jung-Eun Park |
| author_facet | Seung-Hwa Baek Jung-Eun Park |
| author_sort | Seung-Hwa Baek |
| collection | DOAJ |
| description | SADS-CoV, a recently identified <i>Rhinolophus</i> bat coronavirus HKU2-associated swine coronavirus, is a malignant pathogen that causes acute diarrhea, severe diarrhea, and weight loss in infected piglets. The virus was first detected in Guangdong Province, China, in 2017 and has since been observed in Jiangxi, Fujian, and Guangxi Provinces. In 2023, the virus was detected in Henan Province, in inland China. This virus can infect various cell lines, including human cell lines, showing significant potential for cross-species transmission and posing a possible zoonotic threat. However, the molecular biology of SADS-CoV remains largely unknown, and there are no commercially available therapeutics or vaccines to prevent SADS-CoV infection. In this review, an update on progress in SADS-CoV research is provided, with a focus on the history of outbreaks, the characteristics of the virus, its interactions with the host, and developments in therapeutics and vaccines. |
| format | Article |
| id | doaj-art-c913bc94a4844d14a8c5d59fdf3931fd |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-c913bc94a4844d14a8c5d59fdf3931fd2025-01-24T13:17:46ZengMDPI AGAnimals2076-26152025-01-0115214910.3390/ani15020149Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host InteractionsSeung-Hwa Baek0Jung-Eun Park1College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaSADS-CoV, a recently identified <i>Rhinolophus</i> bat coronavirus HKU2-associated swine coronavirus, is a malignant pathogen that causes acute diarrhea, severe diarrhea, and weight loss in infected piglets. The virus was first detected in Guangdong Province, China, in 2017 and has since been observed in Jiangxi, Fujian, and Guangxi Provinces. In 2023, the virus was detected in Henan Province, in inland China. This virus can infect various cell lines, including human cell lines, showing significant potential for cross-species transmission and posing a possible zoonotic threat. However, the molecular biology of SADS-CoV remains largely unknown, and there are no commercially available therapeutics or vaccines to prevent SADS-CoV infection. In this review, an update on progress in SADS-CoV research is provided, with a focus on the history of outbreaks, the characteristics of the virus, its interactions with the host, and developments in therapeutics and vaccines.https://www.mdpi.com/2076-2615/15/2/149swine acute diarrhea syndrome coronavirusvirus-host interactionscross-species transmissionvaccineszoonotic threat |
| spellingShingle | Seung-Hwa Baek Jung-Eun Park Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions Animals swine acute diarrhea syndrome coronavirus virus-host interactions cross-species transmission vaccines zoonotic threat |
| title | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions |
| title_full | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions |
| title_fullStr | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions |
| title_full_unstemmed | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions |
| title_short | Swine Acute Diarrhea Syndrome Coronavirus: An Overview of Virus Structure and Virus–Host Interactions |
| title_sort | swine acute diarrhea syndrome coronavirus an overview of virus structure and virus host interactions |
| topic | swine acute diarrhea syndrome coronavirus virus-host interactions cross-species transmission vaccines zoonotic threat |
| url | https://www.mdpi.com/2076-2615/15/2/149 |
| work_keys_str_mv | AT seunghwabaek swineacutediarrheasyndromecoronavirusanoverviewofvirusstructureandvirushostinteractions AT jungeunpark swineacutediarrheasyndromecoronavirusanoverviewofvirusstructureandvirushostinteractions |