The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population

Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily...

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Main Authors: Jae Woong Sull, Seung-Ju Yang, Soriul Kim, Sun Ha Jee
Format: Article
Language:English
Published: BioMed Central 2014-12-01
Series:Genomics & Informatics
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Online Access:http://genominfo.org/upload/pdf/gni-12-231.pdf
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author Jae Woong Sull
Seung-Ju Yang
Soriul Kim
Sun Ha Jee
author_facet Jae Woong Sull
Seung-Ju Yang
Soriul Kim
Sun Ha Jee
author_sort Jae Woong Sull
collection DOAJ
description Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNP rs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uric acid levels (≥7.0 mg/dL) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 was stronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ≥ 26.4 (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults.
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spelling doaj-art-c90fc5ad65444725a06c5f4d9eb6a9832025-02-02T21:37:32ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-12-0112423123510.5808/GI.2014.12.4.231114The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean PopulationJae Woong Sull0Seung-Ju Yang1Soriul Kim2Sun Ha Jee3Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam 461-713, Korea.Department of Biomedical Laboratory Science, Konyang University, Daejeon 302-718, Korea.Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-752, Korea.Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-752, Korea.Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNP rs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uric acid levels (≥7.0 mg/dL) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 was stronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ≥ 26.4 (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults.http://genominfo.org/upload/pdf/gni-12-231.pdfgenetic polymorphismuric acid
spellingShingle Jae Woong Sull
Seung-Ju Yang
Soriul Kim
Sun Ha Jee
The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
Genomics & Informatics
genetic polymorphism
uric acid
title The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_full The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_fullStr The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_full_unstemmed The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_short The Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_sort polymorphism rs2725220 is associated with hyperuricemia in the korean population
topic genetic polymorphism
uric acid
url http://genominfo.org/upload/pdf/gni-12-231.pdf
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