Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers
The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including the development of resistance, di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526250/full |
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| author | Artemijs Sceglovs Artemijs Sceglovs Ingus Skadins Marco Chitto Juta Kroica Kristine Salma-Ancane Kristine Salma-Ancane |
| author_facet | Artemijs Sceglovs Artemijs Sceglovs Ingus Skadins Marco Chitto Juta Kroica Kristine Salma-Ancane Kristine Salma-Ancane |
| author_sort | Artemijs Sceglovs |
| collection | DOAJ |
| description | The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including the development of resistance, disruption of the microbiota, adverse side effects, and environmental impact, emphasizing the urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) antibacterial properties as a sustainable, next-generation alternative to traditional antibiotics. These biopolymers may address bacterial resistance uniquely by disrupting bacterial membranes rather than cellular functions, potentially reducing microbiota interference. Through a comparative analysis of the mechanisms and applications of antibiotics and antibacterial naturally derived biopolymers, this review highlights the potential of such biopolymers to address AMR while supporting human and environmental health. |
| format | Article |
| id | doaj-art-c8f3bf07ea5543749ce36679a5e3c8a9 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-c8f3bf07ea5543749ce36679a5e3c8a92025-02-03T06:33:52ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-02-011610.3389/fmicb.2025.15262501526250Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymersArtemijs Sceglovs0Artemijs Sceglovs1Ingus Skadins2Marco Chitto3Juta Kroica4Kristine Salma-Ancane5Kristine Salma-Ancane6Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaDepartment of Biology and Microbiology, Riga Stradins University, Riga, LatviaAO Research Institute Davos, Davos, SwitzerlandDepartment of Biology and Microbiology, Riga Stradins University, Riga, LatviaInstitute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaThe global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including the development of resistance, disruption of the microbiota, adverse side effects, and environmental impact, emphasizing the urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) antibacterial properties as a sustainable, next-generation alternative to traditional antibiotics. These biopolymers may address bacterial resistance uniquely by disrupting bacterial membranes rather than cellular functions, potentially reducing microbiota interference. Through a comparative analysis of the mechanisms and applications of antibiotics and antibacterial naturally derived biopolymers, this review highlights the potential of such biopolymers to address AMR while supporting human and environmental health.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526250/fullantibacterial naturally derived biopolymersantibioticsantibiotic resistancebacterial infectionsmechanism of action |
| spellingShingle | Artemijs Sceglovs Artemijs Sceglovs Ingus Skadins Marco Chitto Juta Kroica Kristine Salma-Ancane Kristine Salma-Ancane Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers Frontiers in Microbiology antibacterial naturally derived biopolymers antibiotics antibiotic resistance bacterial infections mechanism of action |
| title | Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers |
| title_full | Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers |
| title_fullStr | Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers |
| title_full_unstemmed | Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers |
| title_short | Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers |
| title_sort | failure or future exploring alternative antibacterials a comparative analysis of antibiotics and naturally derived biopolymers |
| topic | antibacterial naturally derived biopolymers antibiotics antibiotic resistance bacterial infections mechanism of action |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1526250/full |
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