The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease
Abstract Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years h...
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-05-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201506174 |
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| author | Thorsten Kessler Baiba Vilne Heribert Schunkert |
| author_facet | Thorsten Kessler Baiba Vilne Heribert Schunkert |
| author_sort | Thorsten Kessler |
| collection | DOAJ |
| description | Abstract Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome‐wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk‐related genetic variants to new preventive and therapeutic strategies for cardiovascular disease. |
| format | Article |
| id | doaj-art-c8e0ce1ca8a04ea6bb3f076a955178de |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-c8e0ce1ca8a04ea6bb3f076a955178de2025-08-20T03:43:30ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-05-018768870110.15252/emmm.201506174The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular diseaseThorsten Kessler0Baiba Vilne1Heribert Schunkert2Deutsches Herzzentrum München, Klinik für Herz‐ und Kreislauferkrankungen, Technische Universität MünchenDeutsches Herzzentrum München, Klinik für Herz‐ und Kreislauferkrankungen, Technische Universität MünchenDeutsches Herzzentrum München, Klinik für Herz‐ und Kreislauferkrankungen, Technische Universität MünchenAbstract Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome‐wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk‐related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.https://doi.org/10.15252/emmm.201506174atherosclerosiscoronary artery diseasegenome‐wide association studiesmyocardial infarction |
| spellingShingle | Thorsten Kessler Baiba Vilne Heribert Schunkert The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease EMBO Molecular Medicine atherosclerosis coronary artery disease genome‐wide association studies myocardial infarction |
| title | The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease |
| title_full | The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease |
| title_fullStr | The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease |
| title_full_unstemmed | The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease |
| title_short | The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease |
| title_sort | impact of genome wide association studies on the pathophysiology and therapy of cardiovascular disease |
| topic | atherosclerosis coronary artery disease genome‐wide association studies myocardial infarction |
| url | https://doi.org/10.15252/emmm.201506174 |
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