Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation

Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation

Abstract Background Thyroid cancer, characterized by significant genetic and epigenetic alterations, remains a critical focus of molecular oncology. This study investigates eight key genes (BRAF, EIF1 AX, FOXE1, KRAS, PDGFRA, PIK3 CA, PTEN, and TERT) that are deregulated in Hashimoto's Thyroidi...

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Main Authors: Mostafa A. Abdel-Maksoud, Taghreed N. Almana, Saeedah Almutair, Abdulaziz Alamri, Ibrahim A. Saleh, Mohamed Y. Zaky, Wahidah H. Al-Qahtani, Yasir Hameed
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Hereditas
Subjects:
Thyroid cancer
Hashimoto’s Thyroiditis
Diagnosis
Prognosis
Treatment
Online Access:https://doi.org/10.1186/s41065-025-00429-0
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