The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort)
Introduction Infertility has become a major global issue due to the trend of delaying marriage and advanced maternal age. Family/Birth cohort studies are essential for exploring ways to enhance health outcomes at both the individual and societal levels. However, there is a shortage of cohorts that i...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2445183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593959368523776 |
|---|---|
| author | Wei Xiong Qinghan Liang Xiaojie Han Qiaolu Cheng Qihang Liu Xifang Zuo Huiyu Wang Huijing He Guangliang Shan |
| author_facet | Wei Xiong Qinghan Liang Xiaojie Han Qiaolu Cheng Qihang Liu Xifang Zuo Huiyu Wang Huijing He Guangliang Shan |
| author_sort | Wei Xiong |
| collection | DOAJ |
| description | Introduction Infertility has become a major global issue due to the trend of delaying marriage and advanced maternal age. Family/Birth cohort studies are essential for exploring ways to enhance health outcomes at both the individual and societal levels. However, there is a shortage of cohorts that include families who have utilized assisted reproductive technology (ART), particularly initiated at the early stages before pregnancy. The Assisted Reproductive Technology Cohort (APP-Cohort) is a prospective study aiming to investigate the epidemiology and risk factors of adverse gestational outcomes and other health issues in couples who have conceived through ART or naturally.Methods The cohort study’s baseline survey commenced in January 2022 at several locations in Beijing, and enrollment is currently in progress. Both spouses filled out a questionnaire covering demographic, socio-economic, and various modifiable risk factors to gather information on their lifestyle. Physical examinations and biochemical tests were carried out, alongside regular yearly health check-ups throughout pregnancy and childhood. The survey data will be connected to electronic medical records to compile health information on the couples, newborns, and children.Discussion The APP-Cohort study collected data from both wives and husbands before conception, allowing for early assessment of environmental risk factors for maternal and offspring health. With a focus on various types of risk factors such as genetic, environmental, and shared familial traits, the ongoing follow-up of this study will enable researchers to evaluate and distinguish the impacts of these factors on pregnancy outcomes, perinatal health, and children’s health for individuals conceived naturally versus those conceived through ART. By utilizing practical experience and advanced mathematical analysis of the extensive data, the APP-Cohort study will provide valuable insights to promote the administration and success rate of ART in China. |
| format | Article |
| id | doaj-art-c8ddc18c0d974122894978c7afb8eb4e |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-c8ddc18c0d974122894978c7afb8eb4e2025-01-20T08:18:54ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2024.2445183The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort)Wei Xiong0Qinghan Liang1Xiaojie Han2Qiaolu Cheng3Qihang Liu4Xifang Zuo5Huiyu Wang6Huijing He7Guangliang Shan8Department of Gynecology Endocrine & Reproductive Center, National Clinical Research Center for Obstetric & Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaHaidian District Women and Children’s Hospital, Beijing, People’s Republic of ChinaDepartment of Gynecology and Obstetrics, Tongzhou Maternal and Child Health Care Hospital, Beijing, China, People’s Republic of ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of ChinaDepartment of Gynecology and Obstetrics, Tongzhou Maternal and Child Health Care Hospital, Beijing, China, People’s Republic of ChinaHaidian District Women and Children’s Hospital, Beijing, People’s Republic of ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of ChinaDepartment of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, People’s Republic of ChinaIntroduction Infertility has become a major global issue due to the trend of delaying marriage and advanced maternal age. Family/Birth cohort studies are essential for exploring ways to enhance health outcomes at both the individual and societal levels. However, there is a shortage of cohorts that include families who have utilized assisted reproductive technology (ART), particularly initiated at the early stages before pregnancy. The Assisted Reproductive Technology Cohort (APP-Cohort) is a prospective study aiming to investigate the epidemiology and risk factors of adverse gestational outcomes and other health issues in couples who have conceived through ART or naturally.Methods The cohort study’s baseline survey commenced in January 2022 at several locations in Beijing, and enrollment is currently in progress. Both spouses filled out a questionnaire covering demographic, socio-economic, and various modifiable risk factors to gather information on their lifestyle. Physical examinations and biochemical tests were carried out, alongside regular yearly health check-ups throughout pregnancy and childhood. The survey data will be connected to electronic medical records to compile health information on the couples, newborns, and children.Discussion The APP-Cohort study collected data from both wives and husbands before conception, allowing for early assessment of environmental risk factors for maternal and offspring health. With a focus on various types of risk factors such as genetic, environmental, and shared familial traits, the ongoing follow-up of this study will enable researchers to evaluate and distinguish the impacts of these factors on pregnancy outcomes, perinatal health, and children’s health for individuals conceived naturally versus those conceived through ART. By utilizing practical experience and advanced mathematical analysis of the extensive data, the APP-Cohort study will provide valuable insights to promote the administration and success rate of ART in China.https://www.tandfonline.com/doi/10.1080/07853890.2024.2445183Family cohortassisted reproduction technologyreproductive healthadverse gestational outcomesfamily wellbeing |
| spellingShingle | Wei Xiong Qinghan Liang Xiaojie Han Qiaolu Cheng Qihang Liu Xifang Zuo Huiyu Wang Huijing He Guangliang Shan The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) Annals of Medicine Family cohort assisted reproduction technology reproductive health adverse gestational outcomes family wellbeing |
| title | The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) |
| title_full | The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) |
| title_fullStr | The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) |
| title_full_unstemmed | The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) |
| title_short | The rationale, design of the Assisted reproductive technology cohort nested in a pre-pregnancy family cohort (APP-Cohort) |
| title_sort | rationale design of the assisted reproductive technology cohort nested in a pre pregnancy family cohort app cohort |
| topic | Family cohort assisted reproduction technology reproductive health adverse gestational outcomes family wellbeing |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2445183 |
| work_keys_str_mv | AT weixiong therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qinghanliang therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT xiaojiehan therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qiaolucheng therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qihangliu therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT xifangzuo therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT huiyuwang therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT huijinghe therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT guangliangshan therationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT weixiong rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qinghanliang rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT xiaojiehan rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qiaolucheng rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT qihangliu rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT xifangzuo rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT huiyuwang rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT huijinghe rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort AT guangliangshan rationaledesignoftheassistedreproductivetechnologycohortnestedinaprepregnancyfamilycohortappcohort |