Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration

Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration

Abstract Background Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by systemic inflammation with a high short-term mortality rate. Syndecan-1 (SDC-1) can independently predict the 90-day mortality of patients with septic shock. However, the role of SDC-1 in ACLF remains unknown. M...

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Main Authors: Yingli He, Xiaoli Zhang, Yichen Yao, Juan Li, Shan Fu, Yali Feng, Tianzhi Ni, Ruojing Wang, Qiao Zhang, Yushan Liu, Zhijun Liu, Jinfeng Liu, Yuan Yang, Yingren Zhao, Yalei Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medicine
Subjects:
Acute‐on‐chronic liver failure
Syndecan-1
Heparan sulfate
Sulodexide
Liver regeneration
Cell apoptosis
Online Access:https://doi.org/10.1186/s12916-025-03931-4
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