Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells
Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/805975 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565059323166720 |
|---|---|
| author | Claire Pecqueur Lisa Oliver Kristell Oizel Lisenn Lalier François M. Vallette |
| author_facet | Claire Pecqueur Lisa Oliver Kristell Oizel Lisenn Lalier François M. Vallette |
| author_sort | Claire Pecqueur |
| collection | DOAJ |
| description | Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. |
| format | Article |
| id | doaj-art-c8dc8b4d76594ae2a413179f530c1321 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-c8dc8b4d76594ae2a413179f530c13212025-02-03T01:09:36ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/805975805975Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem CellsClaire Pecqueur0Lisa Oliver1Kristell Oizel2Lisenn Lalier3François M. Vallette4Equipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, FranceEquipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, FranceEquipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, FranceEquipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, FranceEquipe Labellisée Ligue Contre le Cancer, Equipe 9 CRCNA, INSERM UMR 892, CNRS UMR 6299, 44007 Nantes, FranceAbnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes.http://dx.doi.org/10.1155/2013/805975 |
| spellingShingle | Claire Pecqueur Lisa Oliver Kristell Oizel Lisenn Lalier François M. Vallette Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells International Journal of Cell Biology |
| title | Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells |
| title_full | Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells |
| title_fullStr | Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells |
| title_full_unstemmed | Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells |
| title_short | Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells |
| title_sort | targeting metabolism to induce cell death in cancer cells and cancer stem cells |
| url | http://dx.doi.org/10.1155/2013/805975 |
| work_keys_str_mv | AT clairepecqueur targetingmetabolismtoinducecelldeathincancercellsandcancerstemcells AT lisaoliver targetingmetabolismtoinducecelldeathincancercellsandcancerstemcells AT kristelloizel targetingmetabolismtoinducecelldeathincancercellsandcancerstemcells AT lisennlalier targetingmetabolismtoinducecelldeathincancercellsandcancerstemcells AT francoismvallette targetingmetabolismtoinducecelldeathincancercellsandcancerstemcells |