Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes
Purpose. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking. Design. Retrospective case series. Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (U...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/2031031 |
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| author | Cosimo Mazzotta Antonio Moramarco Claudio Traversi Stefano Baiocchi Alfonso Iovieno Luigi Fontana |
| author_facet | Cosimo Mazzotta Antonio Moramarco Claudio Traversi Stefano Baiocchi Alfonso Iovieno Luigi Fontana |
| author_sort | Cosimo Mazzotta |
| collection | DOAJ |
| description | Purpose. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking. Design. Retrospective case series. Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2 J/cm2 up to 15 J/cm2, according to the topographic corneal curvature. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, topography, in vivo confocal microscopy (IVCM), and anterior segment optic coherence tomography (AS-OCT) were evaluated preoperatively and at the 1, 3, 6, and 12 months postoperatively. Results. 12 months after surgery UDVA and CDVA did not significantly vary from preoperative values. The average topographic astigmatism decreased from -4.61±0.74 diopters (D) to -3.20±0.81 D and coma aberration improved from 0.95 ± 0.03 μm to 0.88 ± 0.04 μm after surgery. AS-OCT and IVCM documented differential effects on the treated areas using different energies doses. The depths of demarcation line and keratocyte apoptosis were assessed. Conclusions. Preliminary results show correspondence between the energy dose applied and the microstructural stromal changes induced by the cross-linking at various depths in different areas of treated cornea. One year after surgery a significant reduction in the topographic astigmatism and comatic aberration was detected. None of the patients developed significant complications. |
| format | Article |
| id | doaj-art-c8ba4b9327ee43daadb52064c82368fc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-c8ba4b9327ee43daadb52064c82368fc2025-02-03T06:11:41ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/20310312031031Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological OutcomesCosimo Mazzotta0Antonio Moramarco1Claudio Traversi2Stefano Baiocchi3Alfonso Iovieno4Luigi Fontana5Siena Int. Cross-Linking Center, Siena, ItalyOphthalmology Unit, Arcispedale Santa Maria Nuova Hospital-IRCCS, Reggio Emilia, ItalyDepartment of Medical, Surgical and Neurosciences, Ophthalmology Unit, Siena University, Siena, ItalyDepartment of Medical, Surgical and Neurosciences, Ophthalmology Unit, Siena University, Siena, ItalyOphthalmology Unit, Arcispedale Santa Maria Nuova Hospital-IRCCS, Reggio Emilia, ItalyOphthalmology Unit, Arcispedale Santa Maria Nuova Hospital-IRCCS, Reggio Emilia, ItalyPurpose. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking. Design. Retrospective case series. Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2 J/cm2 up to 15 J/cm2, according to the topographic corneal curvature. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, topography, in vivo confocal microscopy (IVCM), and anterior segment optic coherence tomography (AS-OCT) were evaluated preoperatively and at the 1, 3, 6, and 12 months postoperatively. Results. 12 months after surgery UDVA and CDVA did not significantly vary from preoperative values. The average topographic astigmatism decreased from -4.61±0.74 diopters (D) to -3.20±0.81 D and coma aberration improved from 0.95 ± 0.03 μm to 0.88 ± 0.04 μm after surgery. AS-OCT and IVCM documented differential effects on the treated areas using different energies doses. The depths of demarcation line and keratocyte apoptosis were assessed. Conclusions. Preliminary results show correspondence between the energy dose applied and the microstructural stromal changes induced by the cross-linking at various depths in different areas of treated cornea. One year after surgery a significant reduction in the topographic astigmatism and comatic aberration was detected. None of the patients developed significant complications.http://dx.doi.org/10.1155/2016/2031031 |
| spellingShingle | Cosimo Mazzotta Antonio Moramarco Claudio Traversi Stefano Baiocchi Alfonso Iovieno Luigi Fontana Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes Journal of Ophthalmology |
| title | Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes |
| title_full | Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes |
| title_fullStr | Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes |
| title_full_unstemmed | Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes |
| title_short | Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes |
| title_sort | accelerated corneal collagen cross linking using topography guided uv a energy emission preliminary clinical and morphological outcomes |
| url | http://dx.doi.org/10.1155/2016/2031031 |
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