Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography
BackgroundCarotid artery stenosis (CAS) is a common vascular condition that can impair retinal and optic nerve blood supply, leading to ocular ischemic damage. Optical coherence tomography angiography (OCTA) provides a non-invasive method to evaluate retinal microcirculation and detect vascular chan...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1557062/full |
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| author | Zehui Shi Chunqiong Dong Hanfei Tang Hanfei Tang Daqiao Guo Daqiao Guo Xianglian Li Bing Xie Xiao Tang Xiao Tang Xiuping Chen |
| author_facet | Zehui Shi Chunqiong Dong Hanfei Tang Hanfei Tang Daqiao Guo Daqiao Guo Xianglian Li Bing Xie Xiao Tang Xiao Tang Xiuping Chen |
| author_sort | Zehui Shi |
| collection | DOAJ |
| description | BackgroundCarotid artery stenosis (CAS) is a common vascular condition that can impair retinal and optic nerve blood supply, leading to ocular ischemic damage. Optical coherence tomography angiography (OCTA) provides a non-invasive method to evaluate retinal microcirculation and detect vascular changes in CAS patients.MethodsThis study utilized OCTA to evaluate changes in retinal microcirculation in CAS patients before and after carotid artery angioplasty and stenting. A 6 × 6 mm OCTA scan was performed to analyze deep retinal vascular complex (DVC) blood flow density, foveal avascular zone area (FAZA), foveal density within a 300 μm-wide ring surrounding the FAZ (FD-300), and radial peripapillary capillary vessel density (RPC-VD). Additionally, ultra-wide-field OCTA imaging (24 × 20 mm) was employed to comprehensively assess perfusion in both the posterior pole and peripheral retina.ResultsFollowing carotid artery angioplasty and stenting, significant improvements were observed in the ipsilateral eye, including increased macular blood flow density (p = 0.004), FD-300 (p = 0.031), RPC-VD (p = 0.028) and decreased FAZA (p = 0.018) in the deep retinal vascular layer, indicating enhanced retinal microcirculation. No statistically significant changes were found in the contralateral eye. In some cases, ultra-wide-field OCTA revealed a reduction in macular non-perfusion areas in the ipsilateral eye, alongside an increase in non-perfusion areas near the vascular arcades.ConclusionCarotid artery angioplasty and stenting effectively improves retinal microcirculation in CAS patients, as evidenced by increased blood flow density and reduced non-perfusion areas in the ipsilateral eye. OCTA is a valuable non-invasive tool for assessing retinal circulation dynamics, identifying microvascular abnormalities, and monitoring treatment efficacy in CAS patients. |
| format | Article |
| id | doaj-art-c8b79bd63e834b2b89c09dfbf6f90d5f |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-c8b79bd63e834b2b89c09dfbf6f90d5f2025-08-20T03:00:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-03-011910.3389/fnins.2025.15570621557062Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiographyZehui Shi0Chunqiong Dong1Hanfei Tang2Hanfei Tang3Daqiao Guo4Daqiao Guo5Xianglian Li6Bing Xie7Xiao Tang8Xiao Tang9Xiuping Chen10Department of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Vascular Surgery, Zhongshan Hospital of Fudan University, Shanghai, ChinaInstitute of Vascular Surgery, Fudan University, Shanghai, ChinaDepartment of Vascular Surgery, Zhongshan Hospital of Fudan University, Shanghai, ChinaInstitute of Vascular Surgery, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Vascular Surgery, Zhongshan Hospital of Fudan University, Shanghai, ChinaInstitute of Vascular Surgery, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Zhongshan Hospital of Fudan University, Shanghai, ChinaBackgroundCarotid artery stenosis (CAS) is a common vascular condition that can impair retinal and optic nerve blood supply, leading to ocular ischemic damage. Optical coherence tomography angiography (OCTA) provides a non-invasive method to evaluate retinal microcirculation and detect vascular changes in CAS patients.MethodsThis study utilized OCTA to evaluate changes in retinal microcirculation in CAS patients before and after carotid artery angioplasty and stenting. A 6 × 6 mm OCTA scan was performed to analyze deep retinal vascular complex (DVC) blood flow density, foveal avascular zone area (FAZA), foveal density within a 300 μm-wide ring surrounding the FAZ (FD-300), and radial peripapillary capillary vessel density (RPC-VD). Additionally, ultra-wide-field OCTA imaging (24 × 20 mm) was employed to comprehensively assess perfusion in both the posterior pole and peripheral retina.ResultsFollowing carotid artery angioplasty and stenting, significant improvements were observed in the ipsilateral eye, including increased macular blood flow density (p = 0.004), FD-300 (p = 0.031), RPC-VD (p = 0.028) and decreased FAZA (p = 0.018) in the deep retinal vascular layer, indicating enhanced retinal microcirculation. No statistically significant changes were found in the contralateral eye. In some cases, ultra-wide-field OCTA revealed a reduction in macular non-perfusion areas in the ipsilateral eye, alongside an increase in non-perfusion areas near the vascular arcades.ConclusionCarotid artery angioplasty and stenting effectively improves retinal microcirculation in CAS patients, as evidenced by increased blood flow density and reduced non-perfusion areas in the ipsilateral eye. OCTA is a valuable non-invasive tool for assessing retinal circulation dynamics, identifying microvascular abnormalities, and monitoring treatment efficacy in CAS patients.https://www.frontiersin.org/articles/10.3389/fnins.2025.1557062/fulloptical coherence tomography angiographycarotid artery stenosiscarotid artery angioplasty and stentingvascular densityretinal microcirculation |
| spellingShingle | Zehui Shi Chunqiong Dong Hanfei Tang Hanfei Tang Daqiao Guo Daqiao Guo Xianglian Li Bing Xie Xiao Tang Xiao Tang Xiuping Chen Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography Frontiers in Neuroscience optical coherence tomography angiography carotid artery stenosis carotid artery angioplasty and stenting vascular density retinal microcirculation |
| title | Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| title_full | Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| title_fullStr | Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| title_full_unstemmed | Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| title_short | Investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| title_sort | investigation of retinal microcirculation alterations following carotid artery angioplasty and stenting using optical coherence tomography angiography |
| topic | optical coherence tomography angiography carotid artery stenosis carotid artery angioplasty and stenting vascular density retinal microcirculation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1557062/full |
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