Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies

Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies

Poly(ADP-ribosyl)ation (PARylation) is a dynamic protein post-translational modification (PTM) mediated by ADP-ribosyltransferases (ARTs), which regulates a plethora of essential biological processes, such as DNA repair, gene expression, and signal transduction. Among these, PAR-dependent ubiquitina...

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Bibliographic Details
Main Authors: Daoyuan Huang, Jingchao Wang, Li Chen, Weiwei Jiang, Hiroyuki Inuzuka, David K. Simon, Wenyi Wei
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
PARylation ubiquitination
RNF146
tankyrase
Online Access:https://www.mdpi.com/2218-273X/15/2/237
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