One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux tempe...

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Main Authors: B. Siva Kumar, Y. Haranadha Reddy, C. Radha Rani, G. Chnadra Sekhar Reddy
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2011/906320
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author B. Siva Kumar
Y. Haranadha Reddy
C. Radha Rani
G. Chnadra Sekhar Reddy
author_facet B. Siva Kumar
Y. Haranadha Reddy
C. Radha Rani
G. Chnadra Sekhar Reddy
author_sort B. Siva Kumar
collection DOAJ
description α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.
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institution Kabale University
issn 0973-4945
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publishDate 2011-01-01
publisher Wiley
record_format Article
series E-Journal of Chemistry
spelling doaj-art-c8ad7c909c044ab79d914caaa0303fab2025-02-03T01:09:30ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018S1S137S14210.1155/2011/906320One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMGB. Siva Kumar0Y. Haranadha Reddy1C. Radha Rani2G. Chnadra Sekhar Reddy3Department of Chemistry, Vel Tech Engineering College, Avadi, Chennai-600 062, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, Indiaα-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.http://dx.doi.org/10.1155/2011/906320
spellingShingle B. Siva Kumar
Y. Haranadha Reddy
C. Radha Rani
G. Chnadra Sekhar Reddy
One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
E-Journal of Chemistry
title One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
title_full One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
title_fullStr One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
title_full_unstemmed One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
title_short One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
title_sort one pot synthesis and antimicrobial activity of novel α aminophosphonates using tmg
url http://dx.doi.org/10.1155/2011/906320
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