One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG
α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux tempe...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/906320 |
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| author | B. Siva Kumar Y. Haranadha Reddy C. Radha Rani G. Chnadra Sekhar Reddy |
| author_facet | B. Siva Kumar Y. Haranadha Reddy C. Radha Rani G. Chnadra Sekhar Reddy |
| author_sort | B. Siva Kumar |
| collection | DOAJ |
| description | α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity. |
| format | Article |
| id | doaj-art-c8ad7c909c044ab79d914caaa0303fab |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-c8ad7c909c044ab79d914caaa0303fab2025-02-03T01:09:30ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018S1S137S14210.1155/2011/906320One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMGB. Siva Kumar0Y. Haranadha Reddy1C. Radha Rani2G. Chnadra Sekhar Reddy3Department of Chemistry, Vel Tech Engineering College, Avadi, Chennai-600 062, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, IndiaDepartment of Chemistry, Sri Venakateswara University, Tirupati-517 502, Indiaα-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.http://dx.doi.org/10.1155/2011/906320 |
| spellingShingle | B. Siva Kumar Y. Haranadha Reddy C. Radha Rani G. Chnadra Sekhar Reddy One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG E-Journal of Chemistry |
| title | One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG |
| title_full | One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG |
| title_fullStr | One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG |
| title_full_unstemmed | One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG |
| title_short | One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG |
| title_sort | one pot synthesis and antimicrobial activity of novel α aminophosphonates using tmg |
| url | http://dx.doi.org/10.1155/2011/906320 |
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