RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine
Abstract Migraine, a complex disorder, is characterized by recurrent headache episodes. The production of melatonin in the pineal gland, which is crucial for controlling circadian rhythms and sleep–wake cycles, is altered in various conditions, including neurological disorders such as migraine. Rece...
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| Language: | English |
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Nature Portfolio
2024-10-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-73278-y |
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| author | Mansoureh Togha Morvarid Noormohammadi Zeinab Ghorbani Fariba Karimzadeh S. Zahra Bathaie |
| author_facet | Mansoureh Togha Morvarid Noormohammadi Zeinab Ghorbani Fariba Karimzadeh S. Zahra Bathaie |
| author_sort | Mansoureh Togha |
| collection | DOAJ |
| description | Abstract Migraine, a complex disorder, is characterized by recurrent headache episodes. The production of melatonin in the pineal gland, which is crucial for controlling circadian rhythms and sleep–wake cycles, is altered in various conditions, including neurological disorders such as migraine. Recent studies underscore the significance of serum melatonin levels in patients with chronic and episodic migraine, the focus of this study. This case‒control study, conducted from September 2017 to June 2020 in Tehran, Iran, selected potential participants aged 18–65 years from a headache clinic at Sina Hospital (affiliated with Tehran University of Medical Sciences). Both episodic migraine and chronic migraine were diagnosed following the diagnostic criteria in the International Classification of Headache Disorders’ third edition. Melatonin levels were measured according to the instructions of the ELISA kits. There were significant differences in the frequency of headache days and the duration of abortive medication usage between the two groups (P value < 0.001). Besides, analysis revealed significantly lower serum melatonin levels in patients with episodic ((80.45–45.06) 72.83) and chronic migraine ((154.34–63.34) 70.38, P value < 0.001) than in healthy controls (281.25–160.86) 280). Although no considerable differences were found between episodic and chronic migraine patients, the current study demonstrated that serum melatonin levels were substantially greater in healthy controls than in patients with migraine. |
| format | Article |
| id | doaj-art-c8aa9b27eb2a44a19fc8e73730c09745 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c8aa9b27eb2a44a19fc8e73730c097452025-02-02T12:25:24ZengNature PortfolioScientific Reports2045-23222024-10-011411710.1038/s41598-024-73278-yRETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraineMansoureh Togha0Morvarid Noormohammadi1Zeinab Ghorbani2Fariba Karimzadeh3S. Zahra Bathaie4Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Cardiology, Cardiovascular Diseases Research Center, School of Medicine, Heshmat Hospital, Guilan University of Medical SciencesCellular and Molecular Research Centre, Iran University of Medical SciencesDepartment of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares UniversityAbstract Migraine, a complex disorder, is characterized by recurrent headache episodes. The production of melatonin in the pineal gland, which is crucial for controlling circadian rhythms and sleep–wake cycles, is altered in various conditions, including neurological disorders such as migraine. Recent studies underscore the significance of serum melatonin levels in patients with chronic and episodic migraine, the focus of this study. This case‒control study, conducted from September 2017 to June 2020 in Tehran, Iran, selected potential participants aged 18–65 years from a headache clinic at Sina Hospital (affiliated with Tehran University of Medical Sciences). Both episodic migraine and chronic migraine were diagnosed following the diagnostic criteria in the International Classification of Headache Disorders’ third edition. Melatonin levels were measured according to the instructions of the ELISA kits. There were significant differences in the frequency of headache days and the duration of abortive medication usage between the two groups (P value < 0.001). Besides, analysis revealed significantly lower serum melatonin levels in patients with episodic ((80.45–45.06) 72.83) and chronic migraine ((154.34–63.34) 70.38, P value < 0.001) than in healthy controls (281.25–160.86) 280). Although no considerable differences were found between episodic and chronic migraine patients, the current study demonstrated that serum melatonin levels were substantially greater in healthy controls than in patients with migraine.https://doi.org/10.1038/s41598-024-73278-yMelatoninMigraineHeadache |
| spellingShingle | Mansoureh Togha Morvarid Noormohammadi Zeinab Ghorbani Fariba Karimzadeh S. Zahra Bathaie RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine Scientific Reports Melatonin Migraine Headache |
| title | RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine |
| title_full | RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine |
| title_fullStr | RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine |
| title_full_unstemmed | RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine |
| title_short | RETRACTED ARTICLE: Serum melatonin levels and in a sample of Iranian patients with migraine |
| title_sort | retracted article serum melatonin levels and in a sample of iranian patients with migraine |
| topic | Melatonin Migraine Headache |
| url | https://doi.org/10.1038/s41598-024-73278-y |
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