PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial–Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway

PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial–Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway

Environmental pollutants like PM2.5 contribute to chronic rhinosinusitis (CRS). The aryl hydrocarbon receptor (AhR), a contaminant sensor linked to tryptophan metabolites, is regulated by IL4I. However, how PM2.5 stimulation via IL4I1 influences AhR activation and CRS pathogenesis remains unclear. T...

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Bibliographic Details
Main Authors: Yue Wang, Bowen Zheng, Panhui Xiong, Yijun Liu, Longlan Shu, Yang Shen, Tao Lu, Yucheng Yang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Toxics
Subjects:
PM2.5
aryl hydrocarbon receptor
Interleukin 4 Induced 1
nasal mucosal barrier
epithelial–mesenchymal transition
chronic rhinosinusitis
Online Access:https://www.mdpi.com/2305-6304/13/6/488
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