Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture
Bacterial diseases mainly caused by Vibrio species pose a serious threat to shrimp aquaculture and lead to the sudden mass mortalities and huge economics losses. The unfavorable side effects and emergence of superbugs in traditional antibiotic treatment makes development of excellent antibacterial a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513425000171 |
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| author | Cuixia Chen Yangyang Ge Qilong Gu Tianling Wang Yanyan Yang Jinpeng Hu Kang Gao Xing Zhou Hui Li |
| author_facet | Cuixia Chen Yangyang Ge Qilong Gu Tianling Wang Yanyan Yang Jinpeng Hu Kang Gao Xing Zhou Hui Li |
| author_sort | Cuixia Chen |
| collection | DOAJ |
| description | Bacterial diseases mainly caused by Vibrio species pose a serious threat to shrimp aquaculture and lead to the sudden mass mortalities and huge economics losses. The unfavorable side effects and emergence of superbugs in traditional antibiotic treatment makes development of excellent antibacterial agents especially urgent. Antimicrobial peptides (AMPs), which usually have high antibacterial activity and low potential to induce bacterial resistance, are considered as the promising alternatives to conventional antibiotics. However, their anti-Vibrio mechanisms have not yet reached a consensus. In this study, a pathogenic Vibrio strain was isolated from the cultured shrimp and was identified as Vibrio parahaemolyticus UPC-1 (V. Parahaemolyticus UPC-1). Studies showed that G3 efficiently protected shrimp from V. Parahaemolyticus UPC-1 infection through two independent ways. In one way, G3 balanced the bacterial community of shrimp gut by selectively killing the pathogenic Vibrio bacteria. In the other way, G3 markedly reduced the robust inflammation effects induced by Vibrio infection. Such efficient anti-Vibrio activity of G3 endows it great potential in the treatment of Vibrio infections in shrimp aquaculture. |
| format | Article |
| id | doaj-art-c8974fb9d40045dab594b9cb62d34292 |
| institution | Kabale University |
| issn | 2352-5134 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj-art-c8974fb9d40045dab594b9cb62d342922025-02-06T05:12:22ZengElsevierAquaculture Reports2352-51342025-03-0140102631Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquacultureCuixia Chen0Yangyang Ge1Qilong Gu2Tianling Wang3Yanyan Yang4Jinpeng Hu5Kang Gao6Xing Zhou7Hui Li8State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China; Corresponding authors.State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, ChinaState Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, ChinaState Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, ChinaShandong Marine Resource and Environment Research Institute, 216 Changjiang Road, Yantai Economic Development Zone, Yantai 264006, ChinaState Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, ChinaState Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, ChinaQingdao West Coast New Area Marine Development Bureau, Qingdao 266400, ChinaState Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China; Corresponding authors.Bacterial diseases mainly caused by Vibrio species pose a serious threat to shrimp aquaculture and lead to the sudden mass mortalities and huge economics losses. The unfavorable side effects and emergence of superbugs in traditional antibiotic treatment makes development of excellent antibacterial agents especially urgent. Antimicrobial peptides (AMPs), which usually have high antibacterial activity and low potential to induce bacterial resistance, are considered as the promising alternatives to conventional antibiotics. However, their anti-Vibrio mechanisms have not yet reached a consensus. In this study, a pathogenic Vibrio strain was isolated from the cultured shrimp and was identified as Vibrio parahaemolyticus UPC-1 (V. Parahaemolyticus UPC-1). Studies showed that G3 efficiently protected shrimp from V. Parahaemolyticus UPC-1 infection through two independent ways. In one way, G3 balanced the bacterial community of shrimp gut by selectively killing the pathogenic Vibrio bacteria. In the other way, G3 markedly reduced the robust inflammation effects induced by Vibrio infection. Such efficient anti-Vibrio activity of G3 endows it great potential in the treatment of Vibrio infections in shrimp aquaculture.http://www.sciencedirect.com/science/article/pii/S2352513425000171ShrimpVibrio parahaemolyticus (V. Parahaemolyticus)Helical peptide G3Antibacterial activity |
| spellingShingle | Cuixia Chen Yangyang Ge Qilong Gu Tianling Wang Yanyan Yang Jinpeng Hu Kang Gao Xing Zhou Hui Li Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture Aquaculture Reports Shrimp Vibrio parahaemolyticus (V. Parahaemolyticus) Helical peptide G3 Antibacterial activity |
| title | Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture |
| title_full | Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture |
| title_fullStr | Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture |
| title_full_unstemmed | Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture |
| title_short | Dual mechanisms of G3 against Vibrio parahaemolyticus in shrimp aquaculture |
| title_sort | dual mechanisms of g3 against vibrio parahaemolyticus in shrimp aquaculture |
| topic | Shrimp Vibrio parahaemolyticus (V. Parahaemolyticus) Helical peptide G3 Antibacterial activity |
| url | http://www.sciencedirect.com/science/article/pii/S2352513425000171 |
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