Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal

Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal

Itraconazole (ITZ) is a potent antifungal agent. Its oral administration is associated with systemic toxicity, and its efficacy in ocular formulations is limited. This study aims to enhance ITZ’s ocular permeation and antifungal efficacy by loading it into deformable liposomes (DLs) based on Tween 8...

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Bibliographic Details
Main Authors: Mohamed M. Badran, Areej Alsubaie, Mounir M. Salem Bekhit, Abdullah H. Alomrani, Aliyah Almomen
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Gels
Subjects:
Itraconazole
deformable liposomes
coating
in situ gel
cornea
antifungal efficacy
Online Access:https://www.mdpi.com/2310-2861/11/1/19
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