Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases
Abstract Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Neuroinflammation |
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| Online Access: | https://doi.org/10.1186/s12974-025-03334-5 |
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| author | Longxiao Zhang Yunfei Zhou Zhongbo Yang Liangchao Jiang Xinyang Yan Wenkai Zhu Yi Shen Bolong Wang Jiaxi Li Jinning Song |
| author_facet | Longxiao Zhang Yunfei Zhou Zhongbo Yang Liangchao Jiang Xinyang Yan Wenkai Zhu Yi Shen Bolong Wang Jiaxi Li Jinning Song |
| author_sort | Longxiao Zhang |
| collection | DOAJ |
| description | Abstract Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response to diverse pathological stimuli. This article provides a comprehensive review on the composition of LDs in CNS, their generation and degradation processes, their interaction mechanisms with mitochondria, the distribution among different cell types, and the roles played by these cells—particularly microglia and astrocytes—in various prevalent neurological disorders. Additionally, we also emphasize the paradoxical role of LDs in post-cerebral ischemia inflammation and explore potential underlying mechanisms, aiming to identify novel therapeutic targets for this disease. |
| format | Article |
| id | doaj-art-c87ba37f43824a60a457a01281554d75 |
| institution | Kabale University |
| issn | 1742-2094 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj-art-c87ba37f43824a60a457a01281554d752025-01-19T12:33:24ZengBMCJournal of Neuroinflammation1742-20942025-01-0122112810.1186/s12974-025-03334-5Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseasesLongxiao Zhang0Yunfei Zhou1Zhongbo Yang2Liangchao Jiang3Xinyang Yan4Wenkai Zhu5Yi Shen6Bolong Wang7Jiaxi Li8Jinning Song9Department of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Lipid droplets (LDs), serving as the convergence point of energy metabolism and multiple signaling pathways, have garnered increasing attention in recent years. Different cell types within the central nervous system (CNS) can regulate energy metabolism to generate or degrade LDs in response to diverse pathological stimuli. This article provides a comprehensive review on the composition of LDs in CNS, their generation and degradation processes, their interaction mechanisms with mitochondria, the distribution among different cell types, and the roles played by these cells—particularly microglia and astrocytes—in various prevalent neurological disorders. Additionally, we also emphasize the paradoxical role of LDs in post-cerebral ischemia inflammation and explore potential underlying mechanisms, aiming to identify novel therapeutic targets for this disease.https://doi.org/10.1186/s12974-025-03334-5Lipid dropletInflammationLipid metabolismStrokeStress |
| spellingShingle | Longxiao Zhang Yunfei Zhou Zhongbo Yang Liangchao Jiang Xinyang Yan Wenkai Zhu Yi Shen Bolong Wang Jiaxi Li Jinning Song Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases Journal of Neuroinflammation Lipid droplet Inflammation Lipid metabolism Stroke Stress |
| title | Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| title_full | Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| title_fullStr | Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| title_full_unstemmed | Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| title_short | Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| title_sort | lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases |
| topic | Lipid droplet Inflammation Lipid metabolism Stroke Stress |
| url | https://doi.org/10.1186/s12974-025-03334-5 |
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