The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development. Beta HPV types are components of th...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5701639 |
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| _version_ | 1832566300781576192 |
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| author | Mircea Tampa Cristina Iulia Mitran Madalina Irina Mitran Ilinca Nicolae Adrian Dumitru Clara Matei Loredana Manolescu Gabriela Loredana Popa Constantin Caruntu Simona Roxana Georgescu |
| author_facet | Mircea Tampa Cristina Iulia Mitran Madalina Irina Mitran Ilinca Nicolae Adrian Dumitru Clara Matei Loredana Manolescu Gabriela Loredana Popa Constantin Caruntu Simona Roxana Georgescu |
| author_sort | Mircea Tampa |
| collection | DOAJ |
| description | Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development. Beta HPV types are components of the normal flora; however, under the influence of certain cofactors, the virus may trigger a malignant process. Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis. In addition, the oncoproteins E6 and E7 of beta HPV types differ biochemically from their counterparts in the structure of alpha HPV types, resulting in different mechanisms of action in carcinogenesis. The aim of our manuscript is to present an updated point of view on the involvement of beta HPV types in cSCC pathogenesis. |
| format | Article |
| id | doaj-art-c86f696655034a37bb41e12aa3ae6e99 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c86f696655034a37bb41e12aa3ae6e992025-02-03T01:04:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/57016395701639The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell CarcinomaMircea Tampa0Cristina Iulia Mitran1Madalina Irina Mitran2Ilinca Nicolae3Adrian Dumitru4Clara Matei5Loredana Manolescu6Gabriela Loredana Popa7Constantin Caruntu8Simona Roxana Georgescu9“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Victor Babes” Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, RomaniaCutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development. Beta HPV types are components of the normal flora; however, under the influence of certain cofactors, the virus may trigger a malignant process. Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis. In addition, the oncoproteins E6 and E7 of beta HPV types differ biochemically from their counterparts in the structure of alpha HPV types, resulting in different mechanisms of action in carcinogenesis. The aim of our manuscript is to present an updated point of view on the involvement of beta HPV types in cSCC pathogenesis.http://dx.doi.org/10.1155/2020/5701639 |
| spellingShingle | Mircea Tampa Cristina Iulia Mitran Madalina Irina Mitran Ilinca Nicolae Adrian Dumitru Clara Matei Loredana Manolescu Gabriela Loredana Popa Constantin Caruntu Simona Roxana Georgescu The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma Journal of Immunology Research |
| title | The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma |
| title_full | The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma |
| title_fullStr | The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma |
| title_full_unstemmed | The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma |
| title_short | The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma |
| title_sort | role of beta hpv types and hpv associated inflammatory processes in cutaneous squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2020/5701639 |
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