The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor

Abstract Background Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hematopoiesis. The interaction of TCF4 with DNA is dependent on the presen...

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Main Authors: Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar, Aneta Tarczewska
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
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Online Access:https://doi.org/10.1186/s12964-025-02154-7
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