Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos

Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos

IntroductionDue to the impact of antibody-dependent enhancement and viral variation, effective vaccines or antiviral therapies remain lacking for the dengue virus (DENV). Nucleic acid drugs, particularly Vivo-Morpholinos (MOs), have emerged as a promising avenue for antiviral treatment due to their...

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Bibliographic Details
Main Authors: Mengwei Niu, Wenyanbo Yi, Zhuofan Dong, Xiaofeng Li, Xue Dong, Lifang Yu, Yao Han, Oujia Zhang, Ziyang Sheng, Jing An, Hao Li, Yansong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
antisense oligonucleotides
antiviral
dengue virus (DENV)
antisense therapy
nucleic acid therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1491230/full
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