A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity

A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity

Cancer metabolism plays an essential role in therapeutic resistance, where significant inter- and intra-tumoral heterogeneity exists. Hypoxia is a prominent driver of metabolic rewiring behaviors and drug responses. Recapitulating the hypoxic landscape in the tumor microenvironment thus offers uniqu...

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Bibliographic Details
Main Authors: Jeong Min Oh, Tianze Guo, Hydari Masuma Begum, Saci-Elodie Marty, Liang Sha, Cem Kilic, Hao Zhou, Yali Dou, Keyue Shen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Bioactive Materials
Subjects:
Metabolic rewiring
Hypoxia
Tumor heterogeneity
Metabolism-targeting therapy
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25000866
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