Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice

We previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear. It has been recently reported that SGLT2 inhibitors improve chronic kidney disease (CKD)....

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Main Authors: Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata
Format: Article
Language:English
Published: The Japan Endocrine Society 2024-11-01
Series:Endocrine Journal
Subjects:
tofogliflozin
chronic kidney disease (ckd)
inflammation
peroxisome proliferator activated receptor alpha (pparα)
micro-rna-21(mir-21)
Online Access:https://www.jstage.jst.go.jp/article/endocrj/71/11/71_EJ24-0087/_html/-char/en
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