ERBB4 confers metastatic capacity in Ewing sarcoma

ERBB4 confers metastatic capacity in Ewing sarcoma

Abstract Metastatic spread is the single‐most powerful predictor of poor outcome in Ewing sarcoma (ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce the burden of disease in ES. We previously showed that activation of the ERBB4 tyrosine kinase suppresses anoi...

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Bibliographic Details
Main Authors: Ariadna Mendoza‐Naranjo, Amal El‐Naggar, Daniel H. Wai, Priti Mistry, Nikola Lazic, Fernanda Rocha Rojas Ayala, Isabela Werneck da Cunha, Pablo Rodriguez‐Viciana, Hongwei Cheng, Jose H. Tavares Guerreiro Fregnani, Patrick Reynolds, Robert J. Arceci, Andrew Nicholson, Timothy J. Triche, Fernando A. Soares, Adrienne M. Flanagan, Yuzhuo Z. Wang, Sandra J. Strauss, Poul H. Sorensen
Format: Article
Language:English
Published: Springer Nature 2013-05-01
Series:EMBO Molecular Medicine
Subjects:
ERBB4
Ewing sarcoma
FAK
metastasis
Rac1
Online Access:https://doi.org/10.1002/emmm.201202343
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