A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use
A 31-year-old female with a history of lupus nephritis on Hydroxychloroquine, Prednisone, and Mycophenolate Mofetil (MMF) for 10 years presented to the hospital for ankle swelling. On day four, she started to have severe, nonbloody, watery diarrhea with abdominal distension and tenderness. Stool PCR...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/3058407 |
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| _version_ | 1832567195648917504 |
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| author | Abhinav Goyal Moiz Salahuddin Yogesh Govil |
| author_facet | Abhinav Goyal Moiz Salahuddin Yogesh Govil |
| author_sort | Abhinav Goyal |
| collection | DOAJ |
| description | A 31-year-old female with a history of lupus nephritis on Hydroxychloroquine, Prednisone, and Mycophenolate Mofetil (MMF) for 10 years presented to the hospital for ankle swelling. On day four, she started to have severe, nonbloody, watery diarrhea with abdominal distension and tenderness. Stool PCR was negative for C. difficile. CT abdomen/pelvis showed gaseous distension of the colon without any obstruction. Flexible sigmoidoscopy revealed a normal looking mucosa. Histopathology showed crypt atrophy and increased crypt apoptosis, consistent with MMF colitis. The diarrhea resolved three days after stopping MMF. Although generally well tolerated, diarrhea is a common side effect of MMF. Most cases occur in the first six months of starting MMF. This case is unique because it describes MMF colitis in lupus after more than 10 years. Thus, MMF colitis should be considered as a differential in patients taking it, regardless of the duration of use. |
| format | Article |
| id | doaj-art-c82641e29c0748dab0cf97dc43179973 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-c82641e29c0748dab0cf97dc431799732025-02-03T01:02:10ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362016-01-01201610.1155/2016/30584073058407A Unique Case of Mycophenolate Induced Colitis after 10 Years of UseAbhinav Goyal0Moiz Salahuddin1Yogesh Govil2Einstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAEinstein Medical Center, Philadelphia, PA, USAA 31-year-old female with a history of lupus nephritis on Hydroxychloroquine, Prednisone, and Mycophenolate Mofetil (MMF) for 10 years presented to the hospital for ankle swelling. On day four, she started to have severe, nonbloody, watery diarrhea with abdominal distension and tenderness. Stool PCR was negative for C. difficile. CT abdomen/pelvis showed gaseous distension of the colon without any obstruction. Flexible sigmoidoscopy revealed a normal looking mucosa. Histopathology showed crypt atrophy and increased crypt apoptosis, consistent with MMF colitis. The diarrhea resolved three days after stopping MMF. Although generally well tolerated, diarrhea is a common side effect of MMF. Most cases occur in the first six months of starting MMF. This case is unique because it describes MMF colitis in lupus after more than 10 years. Thus, MMF colitis should be considered as a differential in patients taking it, regardless of the duration of use.http://dx.doi.org/10.1155/2016/3058407 |
| spellingShingle | Abhinav Goyal Moiz Salahuddin Yogesh Govil A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use Case Reports in Gastrointestinal Medicine |
| title | A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use |
| title_full | A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use |
| title_fullStr | A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use |
| title_full_unstemmed | A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use |
| title_short | A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use |
| title_sort | unique case of mycophenolate induced colitis after 10 years of use |
| url | http://dx.doi.org/10.1155/2016/3058407 |
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