Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma
BackgroundRecent studies have identified a correlation between inflammation and depression. This study aims to explore the correlation between the red blood cell distribution width (RDW) to albumin ratio (RAR), a practical measure for assessing inflammation, and depression in the general population....
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1504123/full |
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| author | Tingting Shangguan Jing Xu Xiaochun Weng Hao Lin |
| author_facet | Tingting Shangguan Jing Xu Xiaochun Weng Hao Lin |
| author_sort | Tingting Shangguan |
| collection | DOAJ |
| description | BackgroundRecent studies have identified a correlation between inflammation and depression. This study aims to explore the correlation between the red blood cell distribution width (RDW) to albumin ratio (RAR), a practical measure for assessing inflammation, and depression in the general population.MethodsIn this population-based cross-sectional study, data from 28932 adults aged≥18 years old in the NHANES during the period of 1999–2018 were analyzed. To examine the correlation between RAR and depression, multivariate logistic regression analyses, subgroup analyses, restricted cubic spline analyses, and interaction tests were conducted. Furthermore, a mediation analysis was performed to elucidate the role of atherogenic index of plasma (AIP) in mediating the effect of RAR on depression.ResultsMultivariate logistic regression analyses and restricted cubic splines analysis indicated that RAR can exhibit a linearly correlation with depression (OR = 1.335; 95% CI: 1.222, 1.458). Subjects in RAR Q2, Q3, Q4 groups had an increased risk on depression as 22.8%, 22.9% and 51.9% than those in the Q1 group. This positive correlation was more pronounced in those with history of cancers. The ROC analysis indicated that the area under the curve (AUC) for RAR (AUC=0.593) was significantly greater than that for RDW and albumin individually. Mediation analysis indicated that AIP mediated 7.8% of the correlation of RAR with depression.ConclusionsThe findings of this study indicated a significant linear positive correlation between RAR and the prevalence of depression, with AIP serving as a mediator. |
| format | Article |
| id | doaj-art-c82253be369e461baf5df90c81794141 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-c82253be369e461baf5df90c817941412025-01-30T06:22:38ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011610.3389/fpsyt.2025.15041231504123Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasmaTingting Shangguan0Jing Xu1Xiaochun Weng2Hao Lin3Department of Intensive Care Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Ultrasound, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastroenterology, Pingyang Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaBackgroundRecent studies have identified a correlation between inflammation and depression. This study aims to explore the correlation between the red blood cell distribution width (RDW) to albumin ratio (RAR), a practical measure for assessing inflammation, and depression in the general population.MethodsIn this population-based cross-sectional study, data from 28932 adults aged≥18 years old in the NHANES during the period of 1999–2018 were analyzed. To examine the correlation between RAR and depression, multivariate logistic regression analyses, subgroup analyses, restricted cubic spline analyses, and interaction tests were conducted. Furthermore, a mediation analysis was performed to elucidate the role of atherogenic index of plasma (AIP) in mediating the effect of RAR on depression.ResultsMultivariate logistic regression analyses and restricted cubic splines analysis indicated that RAR can exhibit a linearly correlation with depression (OR = 1.335; 95% CI: 1.222, 1.458). Subjects in RAR Q2, Q3, Q4 groups had an increased risk on depression as 22.8%, 22.9% and 51.9% than those in the Q1 group. This positive correlation was more pronounced in those with history of cancers. The ROC analysis indicated that the area under the curve (AUC) for RAR (AUC=0.593) was significantly greater than that for RDW and albumin individually. Mediation analysis indicated that AIP mediated 7.8% of the correlation of RAR with depression.ConclusionsThe findings of this study indicated a significant linear positive correlation between RAR and the prevalence of depression, with AIP serving as a mediator.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1504123/fulldepressionalbuminred blood cell distribution widthcancerinflammation |
| spellingShingle | Tingting Shangguan Jing Xu Xiaochun Weng Hao Lin Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma Frontiers in Psychiatry depression albumin red blood cell distribution width cancer inflammation |
| title | Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma |
| title_full | Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma |
| title_fullStr | Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma |
| title_full_unstemmed | Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma |
| title_short | Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma |
| title_sort | red blood cell distribution width to albumin ratio is associated with increased depression the mediating role of atherogenic index of plasma |
| topic | depression albumin red blood cell distribution width cancer inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1504123/full |
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