First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway

First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway

Cyclin-dependent kinase 9 (CDK9) is a member of the transcription CDK subfamily and plays a role in transcriptional regulation. Selective CDK9 degraders possess potent clinical advantages over reversible CDK9 inhibitors. Herein, we report the first ATG101-recruiting selective CDK9 degrader, AZ-9, ba...

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Bibliographic Details
Main Authors: Ye Zhong, Jing Xu, Huiying Cao, Jie Gao, Shaoyue Ding, Zhaohui Ren, Huali Yang, Yili Sun, Maosheng Cheng, Jia Li, Yang Liu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Protein degradation
Hydrophobic tags
ATG101
Autophagy–lysosome pathway
CDK9
Cyclin T1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002151
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