Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability
Intermittent theta burst stimulation (iTBS) has the potential to enhance corticospinal excitability (CSE) and subsequent motor learning. However, the effects of iTBS following motor learning are unknown. The purpose of the present study was to expl...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/578620 |
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| author | Tino Stöckel Jeffery J. Summers Mark R. Hinder |
| author_facet | Tino Stöckel Jeffery J. Summers Mark R. Hinder |
| author_sort | Tino Stöckel |
| collection | DOAJ |
| description | Intermittent theta burst stimulation (iTBS) has the
potential to enhance corticospinal excitability (CSE)
and subsequent motor learning. However, the effects of
iTBS following motor learning are unknown. The purpose
of the present study was to explore the effect of iTBS
on CSE and performance following motor learning.
Therefore twenty-four healthy participants practiced a
ballistic motor task for a total of 150 movements.
iTBS was subsequently applied to the trained motor
cortex (STIM group) or the vertex (SHAM group).
Performance and CSE were assessed before motor
learning and before and after iTBS. Training
significantly increased performance and CSE in both
groups. In STIM group participants, subsequent iTBS
significantly reduced motor performance with smaller
reductions in CSE. CSE changes as a result of motor
learning were negatively correlated with both the CSE
changes and performance changes as a result of iTBS.
No significant effects of iTBS were found for SHAM
group participants. We conclude that iTBS has the
potential to degrade prior motor learning as a
function of training-induced CSE changes. That means
the expected LTP-like effects of iTBS are reversed
following motor learning. |
| format | Article |
| id | doaj-art-c80ce00a531f4ab0a5fb8ed0e74b5ec9 |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c80ce00a531f4ab0a5fb8ed0e74b5ec92025-08-20T03:19:29ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/578620578620Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal ExcitabilityTino Stöckel0Jeffery J. Summers1Mark R. Hinder2Human Motor Control Laboratory, School of Medicine, University of Tasmania, Private Bag 30, Hobart, TAS 7001, AustraliaHuman Motor Control Laboratory, School of Medicine, University of Tasmania, Private Bag 30, Hobart, TAS 7001, AustraliaHuman Motor Control Laboratory, School of Medicine, University of Tasmania, Private Bag 30, Hobart, TAS 7001, AustraliaIntermittent theta burst stimulation (iTBS) has the potential to enhance corticospinal excitability (CSE) and subsequent motor learning. However, the effects of iTBS following motor learning are unknown. The purpose of the present study was to explore the effect of iTBS on CSE and performance following motor learning. Therefore twenty-four healthy participants practiced a ballistic motor task for a total of 150 movements. iTBS was subsequently applied to the trained motor cortex (STIM group) or the vertex (SHAM group). Performance and CSE were assessed before motor learning and before and after iTBS. Training significantly increased performance and CSE in both groups. In STIM group participants, subsequent iTBS significantly reduced motor performance with smaller reductions in CSE. CSE changes as a result of motor learning were negatively correlated with both the CSE changes and performance changes as a result of iTBS. No significant effects of iTBS were found for SHAM group participants. We conclude that iTBS has the potential to degrade prior motor learning as a function of training-induced CSE changes. That means the expected LTP-like effects of iTBS are reversed following motor learning.http://dx.doi.org/10.1155/2015/578620 |
| spellingShingle | Tino Stöckel Jeffery J. Summers Mark R. Hinder Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability Neural Plasticity |
| title | Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability |
| title_full | Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability |
| title_fullStr | Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability |
| title_full_unstemmed | Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability |
| title_short | Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability |
| title_sort | reversed effects of intermittent theta burst stimulation following motor training that vary as a function of training induced changes in corticospinal excitability |
| url | http://dx.doi.org/10.1155/2015/578620 |
| work_keys_str_mv | AT tinostockel reversedeffectsofintermittentthetaburststimulationfollowingmotortrainingthatvaryasafunctionoftraininginducedchangesincorticospinalexcitability AT jefferyjsummers reversedeffectsofintermittentthetaburststimulationfollowingmotortrainingthatvaryasafunctionoftraininginducedchangesincorticospinalexcitability AT markrhinder reversedeffectsofintermittentthetaburststimulationfollowingmotortrainingthatvaryasafunctionoftraininginducedchangesincorticospinalexcitability |