Blastocyst-Derived Lactate as a Key Facilitator of Implantation
The blastocyst develops a unique metabolism that facilitates the creation of a specialized microenvironment at the site of implantation characterized by high levels of lactate and reduced pH. While historically perceived as a metabolic waste product, lactate serves as a signaling molecule which faci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/100 |
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| _version_ | 1832588933223940096 |
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| author | Kathryn H. Gurner David K. Gardner |
| author_facet | Kathryn H. Gurner David K. Gardner |
| author_sort | Kathryn H. Gurner |
| collection | DOAJ |
| description | The blastocyst develops a unique metabolism that facilitates the creation of a specialized microenvironment at the site of implantation characterized by high levels of lactate and reduced pH. While historically perceived as a metabolic waste product, lactate serves as a signaling molecule which facilitates the invasion of surrounding tissues by cancers and promotes blood vessel formation during wound healing. However, the role of lactate in reproduction, particularly at the implantation site, is still being considered. Here, we detail the biological significance of the microenvironment created by the blastocyst at implantation, exploring the origin and significance of blastocyst-derived lactate, its functional role at the implantation site and how understanding this mediator of the maternal–fetal dialogue may help to improve implantation in assisted reproduction. |
| format | Article |
| id | doaj-art-c80c71c1dad2454380884b2be1b036a1 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-c80c71c1dad2454380884b2be1b036a12025-01-24T13:25:11ZengMDPI AGBiomolecules2218-273X2025-01-0115110010.3390/biom15010100Blastocyst-Derived Lactate as a Key Facilitator of ImplantationKathryn H. Gurner0David K. Gardner1Melbourne IVF, East Melbourne, VIC 3002, AustraliaMelbourne IVF, East Melbourne, VIC 3002, AustraliaThe blastocyst develops a unique metabolism that facilitates the creation of a specialized microenvironment at the site of implantation characterized by high levels of lactate and reduced pH. While historically perceived as a metabolic waste product, lactate serves as a signaling molecule which facilitates the invasion of surrounding tissues by cancers and promotes blood vessel formation during wound healing. However, the role of lactate in reproduction, particularly at the implantation site, is still being considered. Here, we detail the biological significance of the microenvironment created by the blastocyst at implantation, exploring the origin and significance of blastocyst-derived lactate, its functional role at the implantation site and how understanding this mediator of the maternal–fetal dialogue may help to improve implantation in assisted reproduction.https://www.mdpi.com/2218-273X/15/1/100embryoendometrial receptivityIVFmetabolismmetaboloepigenetics |
| spellingShingle | Kathryn H. Gurner David K. Gardner Blastocyst-Derived Lactate as a Key Facilitator of Implantation Biomolecules embryo endometrial receptivity IVF metabolism metaboloepigenetics |
| title | Blastocyst-Derived Lactate as a Key Facilitator of Implantation |
| title_full | Blastocyst-Derived Lactate as a Key Facilitator of Implantation |
| title_fullStr | Blastocyst-Derived Lactate as a Key Facilitator of Implantation |
| title_full_unstemmed | Blastocyst-Derived Lactate as a Key Facilitator of Implantation |
| title_short | Blastocyst-Derived Lactate as a Key Facilitator of Implantation |
| title_sort | blastocyst derived lactate as a key facilitator of implantation |
| topic | embryo endometrial receptivity IVF metabolism metaboloepigenetics |
| url | https://www.mdpi.com/2218-273X/15/1/100 |
| work_keys_str_mv | AT kathrynhgurner blastocystderivedlactateasakeyfacilitatorofimplantation AT davidkgardner blastocystderivedlactateasakeyfacilitatorofimplantation |