Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach
According to the use of Quercus infectoria (QI) and Rosa damascena L. (RD) for therapeutic purposes and lack of adequate information about their cardiovascular effects, we investigated the cardiovascular indices of rabbits which chronically pretreated with these agents. Animal groups were control gr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2013/769143 |
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| author | Siyavash Joukar Masoumeh Askarzadeh Beydolah Shahouzehi Hamid Najafipour Hossein Fathpour |
| author_facet | Siyavash Joukar Masoumeh Askarzadeh Beydolah Shahouzehi Hamid Najafipour Hossein Fathpour |
| author_sort | Siyavash Joukar |
| collection | DOAJ |
| description | According to the use of Quercus infectoria (QI) and Rosa damascena L. (RD) for therapeutic purposes and lack of adequate information about their cardiovascular effects, we investigated the cardiovascular indices of rabbits which chronically pretreated with these agents. Animal groups were control group (CTL), RD and QI groups with normal chow plus 1.5 g RD and QI extracts, respectively, in each kg of the diet for 45 days; Hyperlipidemic (H) group received high-fat diet for 45 days; H+RD and H+QI groups received high fat diet plus QI and RD extracts, respectively. Blood pressure was greater in H+RD group than CTL, RD, and H groups. Left ventricular developed pressure and left ventricular systolic pressure increased significantly in H+RD group versus CTL and RD groups ( and , resp.) and in H+QI groups ( versus QI groups). Left ventricular end diastolic pressure (LVEDP) showed significant reduction in H+QI group versus H group. QI attenuated the values of total cholesterol, LDL, TG, and atherogenic indices of plasma when coadministrated with a high-fat diet. The results suggest the antilipidemic and antiatherogenic effects of QI. In addition, the use of RD along with a high-fat diet may increase the risk of hypertension in rabbits. |
| format | Article |
| id | doaj-art-c80a10d170654bcfb304a3a11c3bbc6e |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-c80a10d170654bcfb304a3a11c3bbc6e2025-02-03T01:12:22ZengWileyJournal of Toxicology1687-81911687-82052013-01-01201310.1155/2013/769143769143Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based ApproachSiyavash Joukar0Masoumeh Askarzadeh1Beydolah Shahouzehi2Hamid Najafipour3Hossein Fathpour4Physiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box 7616914115, IranDepartment of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, IranPhysiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box 7616914115, IranPhysiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box 7616914115, IranDepartment of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, IranAccording to the use of Quercus infectoria (QI) and Rosa damascena L. (RD) for therapeutic purposes and lack of adequate information about their cardiovascular effects, we investigated the cardiovascular indices of rabbits which chronically pretreated with these agents. Animal groups were control group (CTL), RD and QI groups with normal chow plus 1.5 g RD and QI extracts, respectively, in each kg of the diet for 45 days; Hyperlipidemic (H) group received high-fat diet for 45 days; H+RD and H+QI groups received high fat diet plus QI and RD extracts, respectively. Blood pressure was greater in H+RD group than CTL, RD, and H groups. Left ventricular developed pressure and left ventricular systolic pressure increased significantly in H+RD group versus CTL and RD groups ( and , resp.) and in H+QI groups ( versus QI groups). Left ventricular end diastolic pressure (LVEDP) showed significant reduction in H+QI group versus H group. QI attenuated the values of total cholesterol, LDL, TG, and atherogenic indices of plasma when coadministrated with a high-fat diet. The results suggest the antilipidemic and antiatherogenic effects of QI. In addition, the use of RD along with a high-fat diet may increase the risk of hypertension in rabbits.http://dx.doi.org/10.1155/2013/769143 |
| spellingShingle | Siyavash Joukar Masoumeh Askarzadeh Beydolah Shahouzehi Hamid Najafipour Hossein Fathpour Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach Journal of Toxicology |
| title | Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach |
| title_full | Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach |
| title_fullStr | Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach |
| title_full_unstemmed | Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach |
| title_short | Assessment of Safety and Therapeutic Efficacy of Rosa damascena L. and Quercus infectoria on Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach |
| title_sort | assessment of safety and therapeutic efficacy of rosa damascena l and quercus infectoria on cardiovascular performance of normal and hyperlipidemic rabbits physiologically based approach |
| url | http://dx.doi.org/10.1155/2013/769143 |
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