Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis
Background and aimsMultiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. This approach has...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1473414/full |
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| author | Xiaotong Yu Xiaotong Yu Chen Huang Chen Huang Yan Song Yan Song Chun Zhang Chun Zhang Debo You Debo You XuRan Dong XuRan Dong DeFu Wu DeFu Wu Alan Keith Meeker Hao Feng Yuqing Wang Yuqing Wang |
| author_facet | Xiaotong Yu Xiaotong Yu Chen Huang Chen Huang Yan Song Yan Song Chun Zhang Chun Zhang Debo You Debo You XuRan Dong XuRan Dong DeFu Wu DeFu Wu Alan Keith Meeker Hao Feng Yuqing Wang Yuqing Wang |
| author_sort | Xiaotong Yu |
| collection | DOAJ |
| description | Background and aimsMultiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. This approach has received considerable attention from researchers over the past decades. This article aims to provide a bibliometric analysis of the research progress and perspectives on the application of TSA-based mIHC/IF.MethodsWe collected all the TSA-based mIHC/IF documents published between 2007 and 2023 from the Web of Science Core Collection (WoSCC) database. CiteSpace, VOSviewer and Bibliometrix R Package were used to perform the bibliometrics analysis, including details about annual publications, countries, institutions, authors, journals, and research topics and hotspots.ResultsA total of 873 relevant publications (811 articles and 62 reviews) with a time span of 17 years (2007-2023) were obtained. The number of annual publications started to increase rapidly since 2016. The United States (307, 35.17%) and the People’s Republic of China (297, 34.02%) are the top two listed countries for both the number of articles produced and the citations. The University of Texas System (53, 6.07%) was the most productive institution. Integrating these results of hotspot and frontier analysis, TSA-based mIHC/IF provides significant benefits, particularly in neurology, cancer and immunology.ConclusionThis study conducted a comprehensive bibliometric analysis for the use of TSA-based mIHC/IF. As TSA-based mIHC/IF and its associated imaging systems and analytic software progress, it will become the most promising tool for describing the variety of the whole tissue for a better understanding of pathological or physiological behavior. |
| format | Article |
| id | doaj-art-c8082df621c145eb83e4e61d6f592ee5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c8082df621c145eb83e4e61d6f592ee52025-01-24T15:30:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14734141473414Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysisXiaotong Yu0Xiaotong Yu1Chen Huang2Chen Huang3Yan Song4Yan Song5Chun Zhang6Chun Zhang7Debo You8Debo You9XuRan Dong10XuRan Dong11DeFu Wu12DeFu Wu13Alan Keith Meeker14Hao Feng15Yuqing Wang16Yuqing Wang17Cancer Center of Peking University Third Hospital, Beijing, ChinaCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, ChinaCancer Center of Peking University Third Hospital, Beijing, ChinaCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, ChinaOncology Tissue and Imaging Services, Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United StatesOncology Tissue and Imaging Services, Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United StatesCancer Center of Peking University Third Hospital, Beijing, ChinaCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, ChinaBackground and aimsMultiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. This approach has received considerable attention from researchers over the past decades. This article aims to provide a bibliometric analysis of the research progress and perspectives on the application of TSA-based mIHC/IF.MethodsWe collected all the TSA-based mIHC/IF documents published between 2007 and 2023 from the Web of Science Core Collection (WoSCC) database. CiteSpace, VOSviewer and Bibliometrix R Package were used to perform the bibliometrics analysis, including details about annual publications, countries, institutions, authors, journals, and research topics and hotspots.ResultsA total of 873 relevant publications (811 articles and 62 reviews) with a time span of 17 years (2007-2023) were obtained. The number of annual publications started to increase rapidly since 2016. The United States (307, 35.17%) and the People’s Republic of China (297, 34.02%) are the top two listed countries for both the number of articles produced and the citations. The University of Texas System (53, 6.07%) was the most productive institution. Integrating these results of hotspot and frontier analysis, TSA-based mIHC/IF provides significant benefits, particularly in neurology, cancer and immunology.ConclusionThis study conducted a comprehensive bibliometric analysis for the use of TSA-based mIHC/IF. As TSA-based mIHC/IF and its associated imaging systems and analytic software progress, it will become the most promising tool for describing the variety of the whole tissue for a better understanding of pathological or physiological behavior.https://www.frontiersin.org/articles/10.3389/fonc.2024.1473414/fullmultiplex immunohistochemistry/immunofluorescencetyramide signal amplificationbibliometric analysisCiteSpaceVOSviewer |
| spellingShingle | Xiaotong Yu Xiaotong Yu Chen Huang Chen Huang Yan Song Yan Song Chun Zhang Chun Zhang Debo You Debo You XuRan Dong XuRan Dong DeFu Wu DeFu Wu Alan Keith Meeker Hao Feng Yuqing Wang Yuqing Wang Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis Frontiers in Oncology multiplex immunohistochemistry/immunofluorescence tyramide signal amplification bibliometric analysis CiteSpace VOSviewer |
| title | Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis |
| title_full | Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis |
| title_fullStr | Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis |
| title_full_unstemmed | Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis |
| title_short | Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis |
| title_sort | research progress and perspectives on the application of tyramide signal amplification based multiplex immunohistochemistry immunofluorescence a bibliometrics analysis |
| topic | multiplex immunohistochemistry/immunofluorescence tyramide signal amplification bibliometric analysis CiteSpace VOSviewer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1473414/full |
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