MicroRNAs in Postischemic Vascular Repair
The term angiogenesis describes the growth of endothelial sprouts from preexisting postcapillary venules. More recently, this term has been used to generally indicate the growth and remodeling process of the primitive vascular network into a complex network during development. In adulthood, angiogen...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/486702 |
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| author | Andrea Caporali Costanza Emanueli |
| author_facet | Andrea Caporali Costanza Emanueli |
| author_sort | Andrea Caporali |
| collection | DOAJ |
| description | The term angiogenesis describes the growth of endothelial sprouts from preexisting postcapillary venules. More recently, this term has been used to generally indicate the growth and remodeling process of the primitive vascular network into a complex network during development. In adulthood, angiogenesis is activated as a reparative process during wound healing and following ischemia, and it plays a key role in tumor growth and metastasis as well as in inflammatory diseases and diabetic retinopathy. MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that negatively control gene expression of target mRNAs. In this paper, we aim at describing the role of miRNAs in postischemic angiogenesis. First, we will describe the regulation and the expression of miRNAs in endothelial cells. Then, we will analyze the role of miRNAs in postischemic vascular repair. Finally, we will discuss the role of circulating miRNAs as potential biomarkers in ischemic diseases. |
| format | Article |
| id | doaj-art-c8068bad0c994785990940f1414b2ae5 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-c8068bad0c994785990940f1414b2ae52025-02-03T01:25:07ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/486702486702MicroRNAs in Postischemic Vascular RepairAndrea Caporali0Costanza Emanueli1Laboratory of Vascular Pathology and Regeneration, Regenerative Medicine Section, School of Clinical Sciences, Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UKLaboratory of Vascular Pathology and Regeneration, Regenerative Medicine Section, School of Clinical Sciences, Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UKThe term angiogenesis describes the growth of endothelial sprouts from preexisting postcapillary venules. More recently, this term has been used to generally indicate the growth and remodeling process of the primitive vascular network into a complex network during development. In adulthood, angiogenesis is activated as a reparative process during wound healing and following ischemia, and it plays a key role in tumor growth and metastasis as well as in inflammatory diseases and diabetic retinopathy. MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that negatively control gene expression of target mRNAs. In this paper, we aim at describing the role of miRNAs in postischemic angiogenesis. First, we will describe the regulation and the expression of miRNAs in endothelial cells. Then, we will analyze the role of miRNAs in postischemic vascular repair. Finally, we will discuss the role of circulating miRNAs as potential biomarkers in ischemic diseases.http://dx.doi.org/10.1155/2012/486702 |
| spellingShingle | Andrea Caporali Costanza Emanueli MicroRNAs in Postischemic Vascular Repair Cardiology Research and Practice |
| title | MicroRNAs in Postischemic Vascular Repair |
| title_full | MicroRNAs in Postischemic Vascular Repair |
| title_fullStr | MicroRNAs in Postischemic Vascular Repair |
| title_full_unstemmed | MicroRNAs in Postischemic Vascular Repair |
| title_short | MicroRNAs in Postischemic Vascular Repair |
| title_sort | micrornas in postischemic vascular repair |
| url | http://dx.doi.org/10.1155/2012/486702 |
| work_keys_str_mv | AT andreacaporali micrornasinpostischemicvascularrepair AT costanzaemanueli micrornasinpostischemicvascularrepair |