Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells

Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells

Amyloid‐β (Aβ), a primary component of amyloid plaques, has been widely associated with the pathogenesis of Alzheimer's disease. The Ca2+‐binding protein regucalcin (RGN) plays multiple roles in maintaining cell functions by regulating intracellular calcium homeostasis, various signaling pathwa...

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Bibliographic Details
Main Authors: Tomiyasu Murata, Masayoshi Yamaguchi, Susumu Kohno, Chiaki Takahashi, Mitsumi Kakimoto, Yukiko Sugimura, Mako Kamihara, Kiyomi Hikita, Norio Kaneda
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:FEBS Open Bio
Subjects:
Alzheimer's disease
amyloid‐β
apoptosis
mitochondrial dysfunction
reactive nitrogen species
reactive oxygen species
Online Access:https://doi.org/10.1002/2211-5463.12374
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